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Re: NY1972 post# 344

Thursday, 09/22/2016 10:45:16 PM

Thursday, September 22, 2016 10:45:16 PM

Post# of 977
B028 Blockade of the CD47 “Do not eat” signal by TTI-621 (SIRPaFc) leads to enhanced antitumor CD8+ T cell responses in vitro

No STING req'd, innate immune sensing in the TME is a critical step in promoting spontaneous tumor-initiated T cell priming and subsequent
TIL infiltration (Fuertes et al., 2011).