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Re: DewDiligence post# 201850

Monday, 06/27/2016 4:15:18 PM

Monday, June 27, 2016 4:15:18 PM

Post# of 251538
RGLS—RG-101 on FDA clinical hold for SAEs:

http://finance.yahoo.com/news/regulus-reports-clinical-hold-rg-201000470.html

The FDA initiated the clinical hold after Regulus reported a second serious adverse event (SAE) of jaundice. The SAE occurred in a HCV patient with end-stage renal disease on dialysis enrolled in its on-going Phase I US study 117 days after receiving a single dose of RG-101.

The RG-101 HCV program was already on life support; time to pull the plug.

CC at 5pm ET.

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