Monday, June 13, 2016 9:50:57 PM
an important demonstration that additional factors, such as surface-binding geometry or the ability to engage Fc receptors, may modify the response of macrophages to therapeutic antibodies.
In many models, CD47 blockade does not completely eliminate tumors (9, 10, 14). As tumors increase in size, the penetrance of antibody therapies decreases given their high molecular weight (44). Thus, persistent growth may reflect pharmacokinetic limitations in the setting of a rapidly proliferating tumor rather than selection for resistance at the genetic or epigenetic level.
http://www.jci.org/articles/view/81603
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