Amarin Corp Plc (AMRN)

[HDGabor]

sts-

subgroups ... I'd expect secondary endpoints for interim halt are based on the first 6

(Please all patient # will be total cohort , randomized 50-50% between p and V arm)

I do not think they will check the subgroup of the subgroup, since CV Risk Category 2 is a subgroup already, with app. 2,400 patients. If the distribution is equal, (and counting first and second level combo only ... sum: 21) the each subgroup has app. 120 patients.

I think the most likely "certain subgroup" are: Primary endpoint in subset of patients with:
- established CVD (CV Risk Category 1), app 6,600 patients;
- diabetes and at least one additional risk factor for CVD, but no established CVD (CV Risk Category 2), app 2,400 patients;
- diabetes mellitus, 2,400+ patients (could be 4,000 as "Mean and median baseline TGs >200 mg/dL and ~1/2 of patients expected to also have low HDL-C")
[- metabolic syndrome (?)]

Best,
G