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Sunday, 05/24/2015 8:50:27 PM

Sunday, May 24, 2015 8:50:27 PM

Post# of 402568
How do they decide? Look, if you were Dr Menon, how would you possibly know how to dose K for Bologna and for renal cancer(Beth Israel trial with sunitinib, my guess as to the next trial about to be announced)? There is no max dose, and they are about to experiment with new dosing as approved at Dana Farber. But as of yet of course those doses and those effects on p21 or patients are not yet known.

So seriously, how do they pick the doses and intervals? 750 once a week? Or twice a week? Or 1000 or 1250 or 1500 once a week or 3x a week? Will the choices be optimal? Will the difficulty selecting doses hurt the efficacy?

Tough questions, interesting to hear the answers.

We already know how crititcal dosing is- witness what happened when the B dosing was optimized.
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