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Whole Food Diet Linked To Greater Cognitive Dysfunction In Alzheimer’s in Science 2.0, Hank Campbell, February 27th 2015

Excerpt:
"Writing in Neurobiology of Aging, Parrott et al. detail their study using a transgenic mouse model of Alzheimer's Disease and found that a whole food diet caused mice with their equivalent of Alzheimer's to do worse on tests of strategic learning and spatial memory.

Usually, researchers want to know if over-expression of amyloid precursor protein or tau causes the plaque or tangles commonly linked to Alzheimer's Disease, named after the fellow who discovered those qualities in diseased brains, Alois Alzheimer, a century ago. In this paper the researchers wanted to reconcile some animal models, which found that oxidative stress was important, and clinical trials, which showed no benefit using antioxidants that could modulate cell signaling and oxidative stress.

Basically, they wanted to see if there were real-world differences based on diet, so they weaned transgenic (TgCRND8) mice with a whole-food diet, things like salmon, blueberries, kale and brussel sprouts and such, or regular chow.

The results were a bit of a surprise. In mice with Alzheimer's, the whole food diet mice developed worse cognitive function than those fed the control diet - spatial memory and strategic rule learning declined."

Article at:
http://www.science20.com/science_20/whole_food_diet_linked_to_greater_cognitive_dysfunction_in_alzheimers-152777