Re Big Cap Bio - did some research on a few of the biggest bio companies and how well they have been performing lately - especially the last 6 months. The exception is BIIB, which hit its all time high in February and has not been able to retrace yet. But GILD, AMGN, CELG, and REGN have been great performers for large companies. I used closing prices for the following analysis.
GILD - up 47+% YTD; up 44+% last 6 months; up 69% from bottom on 4/10; 23 new all-time closing highs since June; new all-time high and closing high today
AMGN - up 31% YTD; up ~31% last six months; up 34% from low on 5/8; 15 new all-time highs since July; new all-time high yesterday and closing high today
CELG - up 22% YTD; up 46% last six months; up ~51% from low on 4/11; 14 new all-time highs since May; new all-time high and closing high today
REGN - up 46.5% YTD; up 37% last six months; up 41.5% from low on 4/4; 12 new all-time highs since July; new all-time high and closing high today
Personally, I think GILD and AMGN are still pretty cheap and CELG may have best risk/reward ratio. Still think REGN too expensive, but have missed the entire run and know that it might keep running. Mostly think that all of them have better risk/reward than most companies discussed here. Especially for those of us that don't diversify broadly - like me.