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Wednesday, 10/01/2014 6:43:22 AM

Wednesday, October 01, 2014 6:43:22 AM

Post# of 30990
Anatabine and Septic Shock, How many lives would it save?

As we know, anatabine helps regulate the transcription of NF-kB which cascades out of control when a person has sepsis or goes into septic shock.

Septic Shock is just one of hundreds of human ailments where NF-kB can have significant benefits and potentially save thousands of lives. Let's take a look at the suppporting data.

http://www.ncbi.nlm.nih.gov/pubmed/16531564

excerpts...

Abstract

The pathophysiology of sepsis and septic shock involves complex cytokine and inflammatory mediator networks. NF-kappaB activation is a central event leading to the activation of these networks. The role of NF-kappaB in septic pathophysiology and the signal transduction pathways leading to NF-kappaB activation during sepsis have been an area of intensive investigation. NF-kappaB is activated by a variety of pathogens known to cause septic shock syndrome. NF-kappaB activity is markedly increased in every organ studied, both in animal models of septic shock and in human subjects with sepsis. Greater levels of NF-kappaB activity are associated with a higher rate of mortality and worse clinical outcome. NF-kappaB mediates the transcription of exceptional large number of genes, the products of which are known to play important roles in septic pathophysiology. Mice deficient in those NF-kappaB-dependent genes are resistant to the development of septic shock and to septic lethality. More importantly, blockade of NF-kappaB pathway corrects septic abnormalities. Inhibition of NF-kappaB activation restores systemic hypotension, ameliorates septic myocardial dysfunction and vascular derangement, inhibits multiple proinflammatory gene expression, diminishes intravascular coagulation, reduces tissue neutrophil influx, and prevents microvascular endothelial leakage. Inhibition of NF-kappaB activation prevents multiple organ injury and improves survival in rodent models of septic shock. Thus NF-kappaB activation plays a central role in the pathophysiology of septic shock.

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How many people are dying each year from septic shock that could be saved by quick administration of Anatabine? We may never know until someone does a study.

We do know that >750,000 people per year in the US go into Septic Shock (where organs start to fail) and the healthcare cost is > $17 Billion. Countless more suffer from Sepsis.

http://www.world-sepsis-day.org/?MET=SHOWCONTAINER&vCONTAINERID=11

Sepsis is common and often deadly. It remains the primary cause of death from infection, despite advances in modern medicine like vaccines, antibiotics, and intensive care. Often misunderstood as “blood poisoning”, sepsis today is one of the leading causes of death around the world.

Sepsis arises when the body’s response to an infection damages its own tissues and organs. It can lead to shock, multiple organ failure, and death, especially if it is not recognized early and treated promptly. Between one-third and one-half of all sepsis patients die. In developing countries, sepsis accounts for 60-80% of all deaths. It kills more than 6 million infants and young children, and 100,000 new mothers every year. Every few seconds, someone in the world dies of sepsis.


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Now Univ. of North Carolina Researchers have found a link between Sepsis and lipopolysaccharide (LPS). Does LPS sound familiar to anyone? Oh yeah...the Roskamp Institute did research on Anatabine and LPS.

http://news.unchealthcare.org/news/2013/september/unc-researchers-identify-molecule-that-triggers-septic-shock

excerpts....

This increasingly prevalent syndrome, known as septic shock, afflicts more than 750,000 people each year in the United States at a cost of nearly $17 billion.

About half of the cases of septic shock are caused by bacteria that produce LPS, also known as endotoxin. In fact, much of what is known about endotoxic shock comes from studying animals injected with high doses of LPS.

Through a number of experiments in animal models of sepsis, Miao’s team showed that the exterior and interior alarms work together through a two-step defense mechanism: LPS is first seen on the outside of the cell by TLR4, which sets the interior caspase-11 alarm into a watchful state. At very high doses, the LPS crosses into the cell, tripping the caspase-11 alarm. The end result is the generation of the red alert signal, which causes the cell to explode, a form of cell death called pyroptosis. During an infection, the immune system essentially burns the house down around the invading bacteria, depriving it of a place to replicate, and exposing it to more potent immune defenses. During sepsis, however, too much fire leads to the onset of shock.

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What do we know of that prevents LPS induced activation of NF-kB?

It's called Anatabloc (RCP-006) or anatabine citrate, and until the FDA got involved, it was available off the shelf at GNC stores. Let's hope the FDA finds a way for it to be available again soon (either as a nutraceutical or as a drug).

http://www.rfdn.org/inflammaging3.html



The Roskamp Institute is interested in finding new treatments for the diseases of aging associated with chronic inflammation. In this respect Roskamp Institute scientists are examining the properties of RCP006 whose active ingredient is anatabine. In further studies of NF-KB activity and anatabine's ability to decrease it, we see that LPS induced NF-KB activation in human white blood cells is decreased at dose equivalents to aspirin or celebrex (which is toxic at these doses).

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I would humbly suggest that Rock Creek Pharmaceuticals get a clinical trial started ASAP on Sepsis/Septic Shock with a reputable medical institution. IMHO, too many people are dying every day that could have been saved.

JMHO,

NJ

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