After 4 weeks of monotherapy:There were no virologic failures in the first 12 patients. 100% of the patients passed 4 weeks of monotherapy.
•After 8 weeks of monotherapy:There were no virologic failures in six patients. Six patients had virologic failure and are being retested. Of those, two are confirmed to have Dual-Mix virus. Excluding those two patients, 6 of 10 patients (60%) had viral load suppression after 8 weeks of monotherapy compared to nearly 0% in historical controls.
•After 10 weeks of monotherapy:Five patients have not experienced virologic failure;two have now passed 11 weeks of monotherapy with zero failure. However, an additional patient experienced virologic failure at 10thweek of monotherapy. To date, we have 7 patients with virologic failure, two were ruled out, as they were D/M, the other five are being retested.
In regards to second cohort of 28 patients:Four patients received their first dose of PRO 140, with first patient receiving his/her first dose of PRO 140 on August 4, 2014
Since the above update, I'd like to know about the patients who have completed the substitution trial, the new batch who are starting week 5 and if the other virologic failures were also D/M?
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