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Post# of 251543
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Re: genisi post# 181518

Thursday, 08/28/2014 7:19:17 PM

Thursday, August 28, 2014 7:19:17 PM

Post# of 251543
Many thanks, Idit.

It seems that while the tx is probably safe, there wasn't much indication of any effectiveness in humans. Or am I way too early in the study to be disappointed?

The pilot exploratory efficacy analysis of BIIB033 effects on preexisting brain MRI lesions by MTR and DTI did not reveal any clear treatment effects on preexisting T2 or T1 lesions (figure e-2). However, the sample size was too small and the duration of treatment too short to allow any firm conclusions to be drawn. Larger and longer studies are necessary to investigate whether MTR and DTI are sensitive enough to detect treatment effects of candidate treatments for CNS repair such as BIIB033.

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