Wednesday, August 20, 2014 9:07:28 AM
Kevetrin will be first of kind type of chemotherapy by virtue of its effect on p53(remember the first monoclonal antibody to be marketed) It will the next Avastin to which all followers will be compared to in the future.
Brilacidin is a unique class of antibiotic which mimics the cells own protein called a defensin class.
It attaches to the bacterial cell wall and results in rapid disruption and death therefore no time is allowed for resistance to develop.
There is an un meet need in medicine for the treatment of gram negative sepsis and Brilacidin's spectrum looks to fit that role as well.
Everyone here is basing its worth on comparisons to daptomycin but fail to see its use in multiple other life threatening bacterial infections, particularly in immune suppressed and immunocompromised hosts with gram positive and gram negative infections (Klebsiella sepsis in transplant patients)
Once this drug is approved and on formulary infectious disease doctors will use it off label and soon it's true value will be recognized .
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