Avid Bioservices Inc (CDMO)

[goodJohnhunting]

Not a typo or joke,

I wouldn't suggest it unless there were some method to the madness :)

Statin drugs and Bavituximab have always been intriguing by way of
immunomodulatory effect, however the synergy between Bavituximab and Crestor would be different altogether, in regards to Ebola.

It's widely recognized that "viral Ebola replication" requires the cholesterol transporter protein NPC1.

NPCI demonstrates an affinity to bind with glycoprotein, and it's the process of cholesterol transport and GP binding that allow for viral entry, and replication.

I'm suggesting that in combination, Crestor and Bavituximab would both diminish and block these entry point pathways.

Crestor by way of diminished cholesterol transport proteins, and Bavituximab through GP differentiation by way of TIM1, TIM4 binding proteins and attachment to Phosphatidylserine.

Theoretically, Crestor and Bavituximab would overwhelm the "enveloped virulent cell", and block replication.

Or more simply put, take away the "keys" to the vehicle that the virus uses to drive.

All the best,
John