Inovio Pharmaceuticals Inc (INO)

[ImaPseudonym]

This was pretty much expected. It is precisely because it is well documented that the body can clear it naturally that INO thought it would be a good candidate for getting clinical benefit out of increased T-cells. The thought was that if the body can do it naturally, then it must be the t-cells doing it. Increasing the t-cells via therapeutic vaccine should then increase the regression.

There are various estimates for percentage of natural regression from various study. INO stated that they assumed 25% regression, some studies have had as much as 40%. Given the small size of the control group I wouldn't read much into the specific percentage achieved. It could easily have lower or higher if a patient or two had gone the other way.