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Re: TheProgressive post# 58778

Tuesday, 04/22/2014 4:19:22 PM

Tuesday, April 22, 2014 4:19:22 PM

Post# of 402568
Because there are so few patients enrolled in each cohort of a dose escalation study, there is the problem of insufficient sample even at the end of the trial: i.e. 10 total cohorts = less than 36 total patients completed dosing across a wide range of cancers. What that means is the chart must show a clear line of increasing indications of efficacy all the while the primary outcome is only to find the MTD.

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