Kraig Biocraft Laboratories Inc (KBLB)

[ZincFinger]

Why genetic variation is not a problem (and is a dead standard part of all genetic modicication of transgenic animals for production purposes.)

You are failing to distinguish between genetic variation at the site of the genetic modifications and genetic variation elsewhere in the genome. There has been no indication whatsoever at any time whatsoever of unintended genetic variation at the site(s) of genetic modifications using zinc fingers.

There is considerable variation in the Large Commercial Worm (LWC) in parts of the genome not important for silk production (and that is a desirable thing). Such variations do not affect silk but make the worms more robust and resistant to environmental stresses.

Read my past posts carefully what is affecting the silk (adding variability is variations in sequence that are not important to the production of normal silk (and thus not consistent in the LCW) but which ARE important in the production of KBLB's silk with SSP added, almost certainly because of the exceptionally large demand for two amino acids used in much smaller amounts in normal silk. That would explain why selection occurring as a normal part of the ramping up of the MS population caused large improvements in viability, for example.

MS worms are only HALF LCWs, the other half of their genes come from the wild type worm to which the original GMs were made (using the piggyBac transposon which makes random insertions.) the piggyBac was not used at any point in Big Red and all GMs were into EXACT locations with zinc fingers.

Some degree of adaption in other genes is necessary for ANY genetically modified production animal (the effects of genes are highly interrelated) and this should not in any way whatsoever be viewed as an unusual problem In fact, it is a DEAD STANDARD part of the creation of transgenic production organisms (both plants and animals. It's not often discussed precisely because it is so dead standard and very routine to do and occurs during the ramping up of the population and so does not result in undue delays.