OT - protecting yourself from COVID19


https://www.businesswire.com/news/home/20200709005246/en/ChromaDex-Announces-New-Study-Results-Highlighting-Promising

New findings

Conclusions: These results indicate that oral EPA reduces the frequency of SV and CIV after the onset of aneurysmal SAH


https://pubmed.ncbi.nlm.nih.gov/23032083/

Raf
The reason deaths came down is Docs learned how to better care for those critical. Some anti viral drugs and just lots of hard work.

Keep the economy open? Sure. Let’s keep the bars, indoor restaurants and large gatherings going. Who cares if hospitals at 100% capacity? If you need emergency care, just wait in hallway for a few days.


BTW they are learning the inflammation is causing brain damage and heart damage. Yep, very benign.

Hi Raf, what is wrong with this picture?


https://www.dropbox.com/s/xsjlnc0hk9gmgca/US%20vs%20Euro%20Covid.png?dl=0

Raf, perhaps Docs have learned how to treat hospitalized COVID19 patients and improve outcomes.

Dukesking
Yes, very interesting

Raf, all, watch this

"EPA counteracts lipotoxicity in the proximal tubule by alleviating autophagic numbness, making it potentially suitable as a novel treatment for obesity-related kidney diseases."


https://pubmed.ncbi.nlm.nih.gov/32546086/

Double spread collar in Amarin(AMRN) opens bullish position. Shares little changed this morning near $6.80 with a 4-way spread on the ISE where a customer appears to have sold the Sep 5/6 put spread to buy the Sep 7/10 call spread a total of 20k times, opening on all legs. For the largest tranche of 15k, the net credit on the put spread was 27c and the debit on the call spread 77c, for a net debit of 50c, or about $1M on the package. Net delta on the package is nearly 670k shares, or 9% the average daily turnover in the name. Amarin(AMRN) shares dropped nearly 70% from over $13 to $4 on March 31 related to a court ruling. Today's trade could return a 500% gain to the buyer if shares were to return to double digit territory over the next three months.

Kiwi,
Fascinating info on N95 masks

AMRN longs suffering with depression by soon be treated by EPA

"Brain Eicosapentaenoic Acid Metabolism as a Lead for Novel Therapeutics in Major Depression"

https://pubmed.ncbi.nlm.nih.gov/31278982/

A Return to Homeostasis: The Pleiotropic Effects of Eicosapentaenoic Acid (EPA)

https://www.researchgate.net/profile/Jonathan_Eskander/publication/341611357_A_Return_to_Homeostasis_The_Pleiotropic_Effects_of_Eicosapentaenoic_Acid_EPA/links/5ecadfcea6fdcc90d696e7f1/A-Return-to-Homeostasis-The-Pleiotropic-Effects-of-Eicosapentaenoic-Acid-EPA.pdf

?Who knew? Perhaps Vascepa will produce reduce of cytokine storm in #COVID19?


?“Dose-related Effects of EPA on Innate Immune Function in Healthy Humans”?

?https://pubmed.ncbi.nlm.nih.gov/16469992/?

Study: Dose-Dependent Effects of EPA Supplementation on Plasma Specialized Pro-Resolving Mediators in Major Depressive Disorder Patients with Chronic Inflammation


https://academic.oup.com/cdn/article/4/Supplement_2/1538/5845919

“Coronavirus May Be a Blood Vessel Disease, Which Explains Everything”


https://elemental.medium.com/coronavirus-may-be-a-blood-vessel-disease-which-explains-everything-2c4032481ab2

Yep ADAP delivered

Will Vascepa help COVID-19 patients recover faster, avoid death? It appears to me it could.

Watch this video starting at 5 min mark to learn why.

Mineral Oil / evaporate study completed / published


https://academic.oup.com/cardiovascres/article/116/3/479/5673386#.XskgZoLjBZ8.twitter

Conclusions
In our study, low serum EPA levels were associated with cryptogenic stroke with active cancer. This suggests that low serum EPA levels may have some involvement in the pathogenesis of cryptogenic stroke with active cancer.


https://www.sciencedirect.com/science/article/abs/pii/S1052305720302913

Conclusions: In our study, low serum EPA levels were associated with cryptogenic stroke with active cancer. This suggests that low serum EPA levels may have some involvement in the pathogenesis of cryptogenic stroke with active cancer.

https://www.sciencedirect.com/science/article/abs/pii/S1052305720302913

Pfizer Prices $4,000,000,000 Debt Offering
Let the rumors begin ...

Agree, seems a cogent argument

Realities of new normal for Pharma

A good read


https://www.mckinsey.com/industries/pharmaceuticals-and-medical-products/our-insights/covid-19-and-commercial-pharma-navigating-an-uneven-recovery

It’s possible AMRN valuation will be improved sooner by successfully treating the very disease most here dismissed as being hyped .

I suspect Vacsepa will be proven effective (dose dependent) in treating COVID19 by dampening cytokine storm, endothelial dysfunction, oxidative stress, NO production, reduced clotting - all factors in severe COVID19 outcomes.

Don’t expect PR - the initial results / outcomes will be via small clinical studies and shared via KOLS to direct to physicians, assoc.. The halo effect from COVID19 treatment will drive Rx as Vascepa therapeutic value recognized

Again, do not expect pumping PR
Should you have doubts watch MedCram on YouTube to learn how COVID19 is increasingly seen as a CVD issue and less a respiratory via ace2 receptor and cascade into oxidative stress, excessive clotting

Fsulevine see news in Miller’s wife

Tasty, how would you have prevented 70K deaths?

Montana actually your point is a good one but upside down - because most peeps are home bound there are far less deaths (car accidents etc) - 70K deaths in 3 months from COVID 19 with social distancing - How many Flu deaths if we social distanced? Surely a lot less 0 right so you cant compare data without considering measure taken

you need to catch up with science. I suggest you watch a few hours of Med Cram on YouTube

Study finds cases of COVID19
Would have been cut in half if...


https://finance.yahoo.com/news/coronavirus-us-death-toll-halved-093000321.html

Invest2992 - AMRN has to prove first V can be driven to high vol Rx. Pandemic was most unfortunate timing and the patent decision unexpected. BP BO out delayed indefinitely

fsulevine, you are asking for a lot... this same guy makes claims COVID19 is same risk / mortality as Flu

WSJ on COVID19
Like the Flu? Not even close


https://www.wsj.com/articles/coronavirus-hijacks-the-body-from-head-to-toe-perplexing-doctors-11588864248

Invest2992 If you want to go down COVID19 rabbit hole, watch this entirely

Raf, CVD cost to US economy is north of $600 billion / year and going much higher in future years (obesity, demographics)

rtc1110 - I concede your point, but damn the torpedoes... if V can help reduce mortality (and I bet it does because it hits all factors (oxidation, inflammation , endothelial dysfunction, anti thrombosis) AMRN valuation gets adjusted up big time. Prophylactic use will skyrocket from "halo" effect. Its a problem I'm ok having. - also think what it will do for a euro partner deal?

Duke, resist being frustrated - be patient. AMRN KOLS need to recruit Docs to try it, organize a POC trial, then that data supports larger trials. I wouldn't be surprised if Bhatt already recruited some Docs to do a small study. We wont hear until results come out, or if a formal study announced. Its happening - they just cant be pumpers without data

Couldbebetter - I’m confident the opposite is true. It’s highly likely given new understanding how / why COVID19 is causing endothelial dysfunction, thrombosis, inflammation, and oxidative stress that some Docs are looking at V.

Here is a very deep discussion by a doc treating COVID19 that came out yesterday by a doc on front line.
?

?

?Do you know any treatment that helps with endothelial dysfunction, thrombosis, inflammation, and oxidative stress caused by ACE2 impact by COVID19?

?Something tells me $AMRN cultists know ?

?

FFS, most recent protocols that treat CV as a clotting disorder vs respiratory appears to produce better outcomes. Clots appearing throughout body, but particularly in lungs and appears to the cause of pneumonia like condition. Incidence of stroke, MI high. It’s fairly recent observation. Ventilator doesn’t seem to be the best protocol

Best wishes for fast recovery for your family !

This video is a good scientific summary of how dangerous COVID19 is proving to be. The flu doesn’t come close.

This was recorded back on April 15th, since then COVID19 seems to be more of a clotting disorder vs respiratory.

With COVID19 being increasingly classified as a clotting disorder, would seem the anti thrombosis characteristics of Vascepa would be well suited for safely treating COVID-19, plus add the pleiotropic benefits on cellular homeostasis, endothelial lining, more.

https://www.eurekalert.org/pub_releases/2020-05/tmsh-btm050420.php