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RespireRx Pharmaceuticals Inc (RSPI) RSS Feed

Followers
279
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Posts (Total)
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Created
12/30/04
Type
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Moderators oldstocks DTGoody fly_fisherman jacksonjohn
RespireRX Pharmaceuticals Inc. is a biopharmaceutical company focused on the discovery and development of novel drug therapies for the treatment of sleep apnea, ADHD, spinal cord injury and other neurological conditions.


$RSPI

126 Valley Road
Suite C
Glen Rock, NJ 07452

www.respirerx.com

(201) 444-4947
jmargolis@respirerx.com

https://www.resolutionrx.com.au


https://m.youtube.com/watch?time_continue=90&v=3uFrFIOQPz4&embeds_referring_euri=https%3A%2F%2Fwww.primarymarkets.com%2F&embeds_referring_origin=https%3A%2F%2Fwww.primarymarkets.com&source_ve_path=MTM5MTE3LDI4NjY2&feature=emb_logo

 

RespireRx Pharmaceuticals Inc. and its subsidiaries and business units are discovering and developing medicines for the treatment of psychiatric and neurological disorders, with a focus on treatments that address conditions affecting millions of people, but for which there are few or poor treatment options, including epilepsy, pain, attention deficit hyperactivity disorder (“ADHD”), recovery from spinal cord injury (“SCI”), certain neurological orphan diseases and obstructive sleep apnea (“OSA”). The RespireRx Group is developing a pipeline of new and repurposed drug products based on our broad patent portfolios for two drug platforms: (i) neuromodulators, which include GABAkines and AMPAkines, proprietary chemical entities that positively modulate (positive allosteric modulators or “PAMs”) GABAA receptors and AMPA-type glutamate receptors, respectively, and (ii) pharmaceutical cannabinoids, which include dronabinol, a synthetic compound that acts upon the nervous system’s endogenous cannabinoid receptors and

 

The RespireRx Group holds exclusive licenses and owns patents and patent applications or rights thereto for certain families of chemical compounds that claim the chemical structures and their uses in the treatment of a variety of disorders, as well as claims for novel uses of known drugs.





Revolutionary KRM-II-81   New Hope:

KRM-II-81 Drug-Resistant Epilepsy Patients

 
https://www.neurexplain.com/2024/01/17/revolutionary-krm-ii-81-a-new-hope-for-drug-resistant-epilepsy-patients/
 
National Institutes of Health
 A clinical case of a 19-year-old male patient with pharmacoresistant seizures occurring following parieto-occipital tumor-resection at age 6 ...


KRM–II–81 suppresses epileptifom activity across the neural network of cortical tissue from a patient with pharmacoresistant epilepsy

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10784158/

Jodi L. Smith, PhD, MD, FAANS, Director, Pediatric Neurosurgery at Peyton Manning Children’s Hospital at Ascension St. Vincent Medical in Indianapolis, IN led this research effort and is quoted as saying, “I am happy to report that a year after the surgery the patient is seizure-free but remains on seizure medication. Although our research team has observed suppression of activity previously in cortical tissue from epileptic patients, we have now observed recurrent epileptiform bursting in this patient’s tissue. KRM-II-81 fully suppressed the epileptiform bursting, which returned when KRM-II-81 was removed from the incubation medium. We feel that this observation is an impressive indicator for success in translation to patient treatment for this compound.”

Jodi LSmithMD, is a pediatric neurosurgeon at Peyton Manning Children's Hospital at Ascension StVincent Pediatric Neurosurgery in IndianapolisIndiana.
Dr. Jodi L. Smith is an academic pediatric neurosurgeon at James Whitcomb Riley Hospital for Children and an Associate Professor of Neurological Surgery in the Department of Neurological Surgery at the Indiana University Medical Center/Indiana University School of Medicine in Indianapolis, Indiana.


Dr. Smith received her Ph.D. in Anatomy at the University of Utah School of Medicine for her doctoral dissertation studies on "Neurulation." Dr. Smith subsequently completed medical school and residency training in Neurological Surgery at the University of Utah, as well. Following residency, Dr. Smith completed a pediatric neurosurgery fellowship at Children's Hospital, Harvard Medical School in Boston, Massachussetts. Dr. Smith joined the Department of Neurological Surgery at the Indiana University Medical Center/Indiana University School of Medicine in Indianapolis, Indiana in 2000.

Dr. Smith is a Diplomat of the American Board of Neurological Surgery, and her memberships include The Congress of Neurological Surgeons, The American Association of Neurological Surgeons, The American Association of Neurological Surgeons - Pediatric Section, and The Society for Neuroscience.

Dr. Smith is the founder and Co-director of the pediatric surgical epilepsy program at Riley Hospital for Children, Indiana University School of Medicine. Her responsibilities include (1) evaluating pediatric patients with medically refractory epilepsy to determine whether they qualify for surgical treatment of their seizures; and (2) operating on all children with medically refractory epilepsy who are found to be appropriate surgical candidates in order to rid them of their debilitating seizures.

Specialties: Dr. Smith's clinical interests include pediatric epilepsy surgery, brain and spinal cord tumors, brain and spinal cord congenital malformations, hydrocephalus, myelodsyplasia, craniofacial disorders, and Moyamoya syndrome. Dr. Smith's research interests include understanding the cellular and molecular mechanisms of neurulation and understanding the electrophysiological properties of dysplastic/epileptogenic human cortical tissue using a multi channel electrode array.

 
The manuscript’s corresponding author Rok Cerne, MD, PhD, Senior Research Fellow with RepireRx, said that “the bursting activity across a neural network is a unique signature of epilepsy that we were able to observe in the cortical tissue from this patient. Prior to surgery, this 19-year-old patient suffered from seizures in the presence of multiple standard anti-seizure medications. The complete abolishment of these epileptic bursts by our GABAkine is one of most impressive demonstrations we have made to date with KRM-II-81. The data are highly encouraging for us to continue with IND enabling animal studies conducted in collaboration with the National Institutes of Health and to move into the clinic with KRM-II-81.”

https://www.otcmarkets.com/stock/RSPI/news/story?e&id=2731514

Rok CerneMD, PhD, Senior Research Fellow with RepireRx
Rok Cerne. Principal Research Scientist at Eli Lilly and Company. Eli Lilly and Company Iowa State University. Indianapolis, Indiana, United States.

 
 

EndeavourRx: Neuromodulators

 

GABAkines. Under a License Agreement with the University of Wisconsin-Milwaukee Research Foundation, Inc. (“UWMRF”) and on behalf of its EndeavourRx business unit, RespireRx has licensed rights to certain selectively acting GABAkines because of their ability to selectively amplify inhibitory neurotransmission at a highly specific subset of GABAA receptors, thus producing a unique efficacy profile with reduced side effects. Preclinical studies have documented their efficacy in a broad array of animal models of interrelated neurological and psychiatric disorders including epilepsy, pain, anxiety, and depression in the absence of or with greatly reduced propensity to produce sedation, motor-impairment, tolerance, dependence and abuse. EndeavourRx currently is focusing on developing KRM-II-81 for the treatment of epilepsy and pain.

 

KRM-II-81 has displayed a high degree of anti-convulsant activity in a broad range of preclinical studies, including in treatment resistant and pharmaco-resistant models. Not only was KRM-II-81 highly effective in these models, but pharmaco-resistance or tolerance did not develop to its anti-convulsant properties. These latter results are particularly important because pharmaco-resistance occurs when medications that once controlled seizures lose efficacy as a result of chronic use and it is a principal reason some epileptic patients require brain surgery to control their seizures. In support of its potential clinical efficacy, translational studies have demonstrated the ability of KRM-II-81 to dramatically reduce epileptiform electrical activity when administered in situ to brain slices excised from treatment resistant epileptic patients undergoing surgery.

 

In addition, KRM-II-81 has displayed a high degree of analgesic activity in a broad range of preclinical studies. In intact animal models of pain, the analgesic efficacy of KRM-II-81 was comparable to or greater than commonly used analgesics. At the same time, KRM-II-81 did not display side effects such as sedation and motor impairment, but even more importantly, it did not produce tolerance, dependence, respiratory depression or behavioral changes indicative of abuse liability, which are produced by opioid narcotics and are at the heart of the opioid epidemic.

 

AMPAkines. Through an extensive translational research effort from the cellular level through Phase 2 clinical trials, RespireRx has developed a family of novel, low impact AMPAkines, including CX717, CX1739 and CX1942 that may have clinical application in the treatment of CNS-driven neurobehavioral and cognitive disorders, spinal cord injury, neurological diseases, and certain orphan indications. Our lead clinical compounds, CX717 and CX1739, have successfully completed multiple Phase 1 safety trials. Both compounds have also completed Phase 2 proof of concept trials demonstrating target engagement, by antagonizing the ability of opioids to induce respiratory depression.

 

AMPAkines have demonstrated positive activity in animal models of ADHD, results that have been extended translationally into statistically significant improvement of symptoms observed in a Phase 2 human clinical trial of CX717 in adult patients with ADHD. Statistically significant therapeutic effects were observed within one week. We believe AMPAkines may represent a novel, non-stimulant treatment for ADHD with a more rapid onset of action than alternative non-stimulants, such as Straterra® (atomoxetine), and without the drawbacks of amphetamine-type stimulants.

 

In a series of important studies funded by grants from the National Institutes of Health and published in a number of peer reviewed articles, Dr. David Fuller (University of Florida), a long-time RespireRx collaborator, has demonstrated the ability of CX1739 and CX717, RespireRx’s lead AMPAkines, to improve motor nerve activity and muscle function in a number of animal models of spinal cord injury (SCI).

 


ResolutionRx: Pharmaceutical Cannabinoids.



 
ResolutionRx Ltd (Australian Company Number a/k/a ACN 664 925 651) was formed in Australia on January 11, 2023 by RespireRx as an unlisted public company. RespireRx has contributed by sublicense and license with ResolutionRx, its sleep apnea drug development program subject to certain liabilities. ResolutionRx now engages in the research and development (“R&D”) associated with that program, initially for the development of a new formulation of dronabinol for use in a Phase 3 clinical trial and the filing for regulatory approval for the treatment of obstructive sleep apnea (“OSA”). The current total budget for that program over the next several years is approximately US$16.5 million, most, but not all of which is expected to be eligible for the Australian R&D Tax Incentive (“RDTI”). Dronabinol, an endocannabinoid receptor agonist, has already demonstrated significant improvement in the symptoms of OSA in two Phase 2 clinical trials. OSA is a serious respiratory disorder that impacts an estimated 90 million people in the United States, the United Kingdom, Germany and Australia and that has been linked to increased risk for hypertension, heart failure, depression, and diabetes. There are no approved drug treatments for OSA.
 
Because dronabinol is already FDA approved for the treatment of AIDS related anorexia and chemotherapy induced nausea and vomiting, RespireRx and ResolutionRx further believe that its repurposing strategy would only require, in the United States, approval by the FDA of a 505(b)(2) new drug application (“NDA”), an efficient regulatory pathway that allows the use of publicly available data.
 
 
 
On January 18, 2024, the Board of Directors of RespireRx Pharmaceuticals Inc. appointed a new director, Dariusz Nasiek to the Board who is considered to be an outside director.
Dr. Nasiek, MD, MBA, is a dedicated anesthesiologist with expertise in anesthesiology and interventional pain management. Dr. Nasiek is board certified by the American Board of Anesthesiology, the American Board of Pain Medicine and the American Board of Interventional Pain Physicians. Dr. Nasiek is also a Life Member of the American Society of Interventional Pain Physicians and a Member of the International Spine Intervention Society. He has been a practicing physician for the last 35 years. Since 2006, he has been the Managing Partner of Allied Neurology & Interventional Pain Practice, and since 2008, he has served as the Director of Anesthesiology at Hackensack Surgery Center. Dr. Nasiek is a leader specializing in non-surgical options for the treatment of spinal and non-spinal pain and is a pioneer in the use of innovative techniques in the cervical, thoracic and lumbar spine. His forward-looking approaches to pain management, regenerative medicine and tissue healing are described in the new 2nd Edition of his book entitled, “PRP, Platelet Rich Plasma: A New Paradigm in Regenerative Medicine.”


 



COMPANY OFFICERS & CONTACTS
Jeff E. Margolis
CFO, Senior VP, Secretary
 
David Dickason
SVP, Product Dev.
 
Richard D. Purcell, Jr.
SVP, R&D
 
Arnold S. Lippa
CSO, Interim CEO
 
 
BOARD OF DIRECTORS
Arnold S. Lippa
Chairman, CSO, Interim CEO
 
Kathryn MacFarlane
 
 
Jeff E. Margolis
 
 
RSPI SECURITY DETAILS
Share Structure
 
Market Cap Market Cap
858,865
02/15/2024
 
Authorized Shares
2,000,000,000
02/13/2024
 
Outstanding Shares
660,665,615
02/13/2024
 
Restricted
Not Available
 
Unrestricted
Not Available
 
Held at DTC
630,838,088
02/13/2024
 
Float
77,946,750
05/27/2022
 
SEC Filings
FORM TYPE
RECEIVED
PERIOD END DATE
REPORT
8-K 02/02/2024 01/30/2024 PDFRTFHTMLXLS
8-K 01/22/2024 01/18/2024 PDFRTFHTMLXLS
8-K 12/11/2023 12/06/2023 PDFRTFHTMLXLS
10-Q 11/17/2023 09/30/2023 PDFRTFHTMLXLS
NT 10-Q 11/14/2023 09/30/2023 PDFRTFHTML
8-K 10/12/2023 10/09/2023 PDFRTFHTMLXLS
8-K 10/02/2023 09/26/2023 PDFRTFHTMLXLS
10-Q 08/21/2023 06/30/2023 PDFRTFHTMLXLS
NT 10-Q 08/14/2023 06/30/2023 PDFRTFHTML
8-K 08/09/2023 08/03/2023 PDFRTFHTMLXLS
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Readers are advised to conduct their own due diligence prior to considering buying or selling any stock.
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