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GenVec Inc (fka GNVC) RSS Feed

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Web-site - http://www.genvec.com/
Quote -
http://finance.yahoo.com/q/ks?s=GNVC                                                                             

Feb'10 Presentation

Recent Conf Call - http://www.genvec.com/go.cfm?do=Page.View&pid=79

GenVec, Inc., a biopharmaceutical company, develops gene-based therapeutic drugs and vaccines. The company's gene-based therapeutic product candidates use its proprietary adenovector technology platform to deliver genes that produce medically beneficial proteins directly at the site of disease. Its lead product candidate, TNFerade Biologic, is an adenovector that contains the gene for tumor necrosis factor-alpha (TNF-alpha), an immune system protein with anti-cancer effects. Administered by injection directly into tumors, TNFerade Biologic stimulates the production of TNF-alpha in the tumor. GenVec is developing TNFerade Biologic, which is in phase II/III clinical trial ("PACT") for use in treating advanced pancreatic cancer, in Phase II clinical trials for use in treating in rectal cancer and melanoma, and in Phase I/II clinical trail for use in treating head and neck cancer.    It also develops TherAtoh to restore hearing and balance function through the regeneration of critical cells of the inner ear. Further, the company's vaccine programs utilize the adenovector technology platform and its proprietary 293-ORF6 cell line to develop vaccine candidates for infectious diseases, such as HIV, malaria, and influenza, as well as vaccine and anti-viral product candidates for the prevention and containment of foot and mouth disease. It has collaboration agreements with the Agricultural Research Service of the United States Department of Agriculture; the Naval Medical Research Center; the Malaria Vaccine Initiative; the Vaccine Research Center of the National Institute of Allergy and Infectious Diseases; National Institutes of Health; and Fuso Pharmaceuticals Industries, Ltd.

TNFerade / May '09 in Cancer Gene Therapy - #1 (complete paper)  -http://investorshub.advfn.com/boards/read_msg.aspx?message_id=39895011

TNFerade / May '09 in Cancer Gene Therapy - #2 - http://www.ncbi.nlm.nih.gov/pubmed/19444305

JCO Paper - p1 trial -  http://jco.ascopubs.org/cgi/reprint/22/4/592.pdf

Pancreatic Dose-Escalation p2 trial - http://www.genvec.com/download/2006%20ASGT%20SenzerOralPanCanFO.pdf

PACT Trial:

                                          on Clincial_Trials.gov - http://www.clinicaltrials.gov/ct2/show/NCT00051467

ASCO'07 - http://www.genvec.com/download/ASCO%202007%20Poster%20Handout%20FINAL%20OUT.pdf

Nov'08 1st Interim Look Top-Line Results - http://www.genvec.com/download/press/PACT%20Interim%20Data_FINAL.pdf

ASCO'09 1st Interim Look - http://tinyurl.com/ASCO-PACT-09

HR = 0.753 (actual)                                                               HR = 0.753 (ASCO winning prediction)

MS benefit (nonparametric) = 0.0 months (0%)

MS benefit  (parametric / log) = 2.4 months (28%)

75% percentile S(t) benefit = 7.6 months (64%)

25% percentile S(t) benefit = 2.0 months (40%) 


 Head+Neck pI/pII trial - http://www.genvec.com/download/ASCO2008_H&N_FINAL_OUT_28MAY08.pdf

Dendritic Vaccine & TNFerade metastatic PanCa - p2 trial - http://www.clinicaltrials.gov/ct2/show/NCT00868114

Esophageal Cancer pI/pII trial http://www.genvec.com/download/2010%201.7%20FINAL%20OUT%20ASCO%20GI%20Esophageal.pdf

Prostate Cancer pI trial - http://www.clinicaltrials.gov/ct2/show/NCT01048151


Hearing & Balance, Novartis partnership - http://www.genvec.com/download/press/2010%2001.19%20Novartis%20Press%20Release.pdf


FMD (Foot & Mouth) Vaccine Program -

A Safer, Better Vaccine - http://investorshub.advfn.com/boards/read_msg.aspx?message_id=38646546

National Veterinary Stockpile by end 2009 - http://investorshub.advfn.com/boards/read_msg.aspx?message_id=38639522

Internatiional Drive Launched - http://investorshub.advfn.com/boards/read_msg.aspx?message_id=39894886

GNVC website FMD Vaccine presentationhttp://investorshub.advfn.com/boards/read_msg.aspx?message_id=38764457

 

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