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Transgenomic Inc. (TBIO)

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Last Post: 5/16/2015 9:05:02 PM - Followers: 15 - Board type: Free - Posts Today: 0

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Link to coporate website:
http://www.transgenomic.com/

TICKER SYMBOL:TBIO
Share Structure
Market Value1 $40,142,705 a/o May 10, 2013
Shares Outstanding 88,225,725 a/o Mar 13, 2013
Float Not Available
Authorized Shares 100,000,000 a/o Aug 02, 2011
Par Value 0.01

TRANSFER AGENT:
Wells Fargo Bank Minnesota, N.A.
Shareowner Services
P.O. Box 64854
St. Paul, MN 55164-0854
Phone: 877-602-7611

About:
Transgenomic is a global biotechnology company that provides unique products and services for automated high sensitivity genetic variation and mutation analysis. Our offerings include systems, products, discovery and laboratory testing services to the academic and medical research, clinical laboratory and pharmaceutical markets in the fields of pharmacogenomics and personalized medicine.

Transgenomic offers its WAVE® DHPLC Systems and associated consumables. These systems are specifically designed for use in genetic variation detection and single- and double-strand DNA/RNA analysis and purification and have broad applicability to genetic research. To date there have been over 1600 systems shipped to more than 30 countries.

Transgenomic's SURVEYOR® Mutation Detection Kits and the SURVEYOR Check-It Kit provide reagents and protocols for the detection of mutations in DNA.

Transgenomic's Cytogenetics offering includes HANABI automated chromosome harvesting systems that improve laboratory productivity with consistent quality compared to manual methods.

Transgenomic Clinical Reference Laboratory provides reference laboratory services specializing in molecular diagnostics including Mitochondrial Disorders, Oncology and Hematology, Molecular Pathology and Inherited Diseases.

Transgenomic Genomic Research Services is a CRO for pharmacogenomic, translational research and clinical trials.



Colorectal Cancer Testing



Very important AMGEN signs collaberation deal with Mgmt:

"Another potential meaningful near-term contributor to the Lab Services segment (as well as to the Diagnostic Tools segment) relates to the recently consummated agreement with Amgen (NasdaqGS:AMGN) whereby the two companies are collaborating on a KRAS an NRAS gene mutation assay kit to screen patients for colorectal cancer.  The RAScan test is currently available for research use only (RUO) in the U.S. (which will run through Lab Svcs) and for clinical use in Europe - which could help accelerate instrument placements (through Menarini) as well as increase consumables sales"



CRC RAScan™ is a new mutation detection test designed to screen for selected KRAS and NRAS mutations (collectively referred to as “RAS mutations”), in patients with metastatic colorectal cancer (mCRC).The identification of these RAS mutations can give physicians important clinical information to help them make better treatment decisions for their mCRC patients.

KRAS and NRAS are part of the RAS family of genes which encode proteins involved in transmitting signals within cells. When Ras proteins are “switched on” by incoming signals, other genes involved in cell growth, differentiation, and survival are activated. Mutations in KRAS, NRAS and other related genes can lead to Ras proteins becoming permanently activated, causing overactive signaling even in the absence of incoming signals, and can lead to the uncontrolled cell growth that characterizes cancer. Mutations that permanently activate Ras proteins are found in ~25% of human tumors and up to 90% of certain cancers. About 40% of colorectal tumors carry KRAS gene mutations and these mutations have been associated with poor response to EGFR antagonists such as cetuximab and panitumumab. Therefore KRAS mutation status can be used to determine whether or not a patient with colorectal cancer will respond to anti-EGFR therapy.

The CRC RAScan test can identify mCRC patients who have RAS mutations at levels that cannot be detected using traditional Sanger Sequencing methods.

CRC RAScan™ for Colorectal Cancer Tumor Testing is available immediately from Transgenomic’s CLIA-certified laboratory in the United States. For more information on this test, click here.

CRC RAScan Mutation Detection Kits will soon be available in the U.S for research use only. CRC RAScan Mutation Detection Kits include the following kits based on Transgenomic's proprietary SURVEYOR® Nuclease technology:

  • KRAS Exon 2
  • KRAS Exons 3 & 4
  • NRAS Exons 2, 3 & 4

Zacks analyst ~ OUR 2013 OUTLOOK~

We've again made some updates to our model.  We now model 2013 revenue of $32.4 million, implying growth of 3% from 2012.  We look for Laboratory Services and Instruments to generate revenue of $20.0 million (+4%) and $12.4 million (+2%), respectively.  We think net income and EPS come in at ($12.7) million and ($0.14).


2013 ASCO CONFERENCE ABSTRACT

http://www.amgen.com/media/media_pr_detail.jsp?year=2013&releaseID=1820728




May. 15, 2013 AMGEN PRESS RELEASE
New Analyses Identify Predictive Biomarkers For Vectibix® (Panitumumab) In Patients With Metastatic Colorectal Cancer

Biomarker Analysis From Phase 3 PRIME ('203) Study and Phase 2 PEAK ('509) Study Link Additional RAS Gene Mutations to Vectibix Clinical Response

THOUSAND OAKS, Calif., May 15, 2013 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced results from three analyses of Vectibix® (panitumumab) in combination with FOLFOX, an oxaliplatin-based chemotherapy regimen, as a first-line treatment for metastatic colorectal cancer (mCRC). These analyses include the description of new predictive biomarkers of clinical response to Vectibix, activating mutations in KRAS (beyond exon 2) and mutations in NRAS, collectively referred to as RAS.

"Amgen helped establish KRAS gene mutation as a biomarker for lack of response to anti-EGFR treatment," said Sean E. Harper, M.D., executive vice president of Research and Development at Amgen. "The identification of new biomarkers may further help to identify appropriate patients with this incurable disease for such treatment."

 









Contact Information:
Phone: (402) 452-5437
E-mail: investorrelations@transgenomic.com

SEC Filings:
http://www.nasdaq.com/asp/quotes_sec.asp?page=filings&symbol=TBIO&selected=TBIO&rpage=sec&


Press Releases:
http://finance.yahoo.com/q?s=TBIO.OB








   
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PostSubject
#335   $TBIO recent news/filings stocktrademan 05/16/15 09:05:02 PM
#334   Interesting Article on "Liquid Biopsies." laser777 05/11/15 03:28:08 PM
#333   § TBIO 1.87 § ipulator_man 04/20/15 01:21:15 PM
#332   Agreed. I'm optimistic and will continue to stay Cre8NuWorldz 04/20/15 10:45:10 AM
#331   TBIO got some good news ..chart not great Roy London 04/20/15 08:47:02 AM
#330   Added more @ 1.54 today. going to take-off soon...? ipulator_man 04/16/15 08:07:14 PM
#329   Thanks ip! trendy123 03/19/15 04:09:47 PM
#328   I was expecting that news last Friday. It ipulator_man 03/19/15 03:56:54 PM
#327   ip, are they still planning on launching the trendy123 03/18/15 03:31:22 PM
#326   Thin is as thin does... ipulator_man 03/18/15 11:01:51 AM
#325   I hope so!!! trendy123 03/16/15 05:06:48 PM
#324   § TBIO 1.70 § ipulator_man 03/16/15 03:47:05 PM
#323   AIGH Investment Partners reports 8.8% ipulator_man 03/13/15 01:53:51 PM
#322   That's exactly what it is..accumulation trendy123 03/11/15 04:12:11 PM
#321   you r welcome! trendy123 03/11/15 04:10:41 PM
#320   Nice 100K changing hands! ipulator_man 03/11/15 12:49:22 PM
#319   § TBIO In @ 1.54 § ipulator_man 03/11/15 11:18:37 AM
#318   Thanks. Moeclay 03/11/15 08:10:27 AM
#317   http://finance.yahoo.com/news/transgenomic-expands-license-agreement-exiqon-1115 trendy123 03/11/15 07:33:53 AM
#316   This stock is garbage. It can't break into Moeclay 03/05/15 01:06:40 PM
#314   Gene-o-techs HUGE!!! ipulator_man 02/21/15 11:25:56 PM
#313   § TBIO 3.90 § ipulator_man 01/29/15 09:14:45 PM
#312   Nice chart! HoaxDevil 01/27/15 04:20:31 PM
#311   THE NEWS WE HAVE BEEN WAITING FOR..... laser777 01/14/15 08:57:26 AM
#310   Listing to Nasdaq Friday! Marvy 05/08/14 11:12:57 AM
#309   S.B.A., I have been following Jenne for two cloveless0976 02/15/14 10:54:54 PM
#308   Renee, This is a very good sign, I went cloveless0976 02/15/14 10:47:50 PM
#307   TBIO one for 12 reverse split: Renee 01/27/14 04:49:59 PM
#306   TBIO Video Chart 12/16/13 MissionIR 12/16/13 11:54:34 AM
#305   pssst... keep this under yre hat <bg> Old Hillbilly 10/15/13 05:29:44 PM
#304   I like these "under the I hub BS" Old Hillbilly 09/16/13 11:50:36 AM
#303   just home buying this and more arwr tomorrow JUST 10-11-12 08/08/13 04:56:18 PM
#302   Quest Diagnostics Introduces Comprehensive Opioid Therapy Genetic Test ~S.B.A.~ 08/08/13 04:04:50 PM
#301   Great News out ! ~S.B.A.~ 08/08/13 04:02:01 PM
#300   Another Stockboardassets dog! Great work! alexwv 07/24/13 04:51:19 PM
#299   70000 shares by NITE at .47 on the gator16 07/23/13 11:51:48 AM
#298   On a rip will jump in if support ~S.B.A.~ 07/23/13 08:23:37 AM
#297   this is showing signs Roy London 07/22/13 11:45:26 PM
#296   ~ $TBIO ~ Daily Par Sar Buy Signal Penny Roger$ 07/22/13 10:27:46 PM
#295   Someone is buying a ton of TBIO today gator16 07/15/13 01:33:21 PM
#294   still looks like .35 then .30 to me.....good luck etradeedge 06/04/13 12:22:08 PM
#293   looks like the market answered my question. Dead gator16 06/04/13 09:43:20 AM
#292   How do you view the news. Low Med gator16 06/04/13 08:10:40 AM
#291   http://finance.yahoo.com/news/transgenomic-apocell-present-results-lung-14300096 ~S.B.A.~ 06/03/13 08:42:26 PM
#290   38.2% fib retrace touched. Healthy trading as we ~S.B.A.~ 06/03/13 07:55:06 PM
#289   Agreed, sell-off today, but large bids in the ~S.B.A.~ 06/03/13 03:42:39 PM
#288   oscillators are coming off the wheels gator16 06/03/13 02:05:10 PM
#287   It's over gator16 06/03/13 12:37:34 PM
#286   The oscillators are coming off support and are ~S.B.A.~ 06/02/13 09:32:04 PM
#285   Low Volume here on TBIO and downward intraday alexwv 06/01/13 10:11:11 AM
PostSubject