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Threshold Pharmaceuticals Inc. (THLD)

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Last Post: 5/28/2016 9:06:55 PM - Followers: 141 - Board type: Free - Posts Today: 4

Threshold Pharmaceuticals, Inc (THLD)



Company Address:
1300 Seaport Boulevard, Suite 500

Redwood City, CA 94063



CIK:  0001183765

is a biotechnology company focused on the discovery and development of therapeutics based on Tumor Hypoxia, a powerful scientific platform that offers broad potential to treat most solid tumors. By selectively targeting tumor cells, we are building a pipeline of drugs that hold promise to be more effective and less toxic to healthy tissues than conventional drugs.





Clinical Pipeline:

Product Pipeline: 
TH-302 is a hypoxia-activated prodrug (HAP) for the potential treatment of solid tumors. TH-302, which was discovered at Threshold, is a novel drug candidate that is activated under the metabolic conditions typical of cancer cells. We filed an IND (Investigational New Drug) with the FDA in April 2007 and started a Phase 1 clinical trial in July 2007. We initiated a second clinical trial of TH-302 in August 2008. This Phase 1/2 clinical trial is also focused on treating solid tumors.

Glufosfamide has been investigated for the potential treatment of pancreatic cancer, small cell lung cancer, platinum-resistant ovarian cancer and advanced soft tissue sarcoma. The soft tissue sarcoma trial provided evidence of clinical activity. Additionally, in a phase 2 clinical trial of glufosfamide in combination with gemcitabine for the treatment of advanced pancreatic cancer, the data indicated that glufosfamide plus gemcitabine may benefit patients with chemotherapy naive pancreatic cancer. The Company will be seeking a partner to continue development of glufosfamide in cancer.

2-Deoxyglucose, or 2DG, for the treatment of solid tumors, has been evaluated in a Phase 1 clinical trial alone and in combination with Taxotere.


Recent News:







Transfer Agent:
Mellon Investor Services LLC
85 Challenger Road
Ridgefield Park, NJ 07660

BNYMellon Shareowner Services


Share Structure:

Outstanding Shares

33,702,242 as of Oct 31, 2010


Authorized Shares

150,000,000 as of Sep 30, 2010


Preferred Shares Authorized

2,000,000 as of Sep 30, 2010


No Preferreds Issued or Outstanding as of Sep 30, 2010





Investor Relations:
Denise T. Powell
Threshold Pharmaceuticals






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Current Price
Bid Ask Day's Range
THLD News: What to Look for in These Biotech Stocks? Threshold Pharma, Seattle Genetics, Chiasma, and Ophthotech 05/18/2016 08:38:00 AM
THLD News: Quarterly Report (10-q) 05/05/2016 06:10:40 PM
THLD News: Current Report Filing (8-k) 05/05/2016 04:46:33 PM
THLD News: Threshold Pharmaceuticals Reports First Quarter Financial Results 05/05/2016 04:02:00 PM
THLD News: Additional Proxy Soliciting Materials (definitive) (defa14a) 04/29/2016 05:08:32 PM
#3219   See Post#3217 which involves THLD's participation. trop 05/28/16 09:06:55 PM
#3218   What's so significant about these dates? Jclassy 05/28/16 05:12:03 PM
#3217 trop 05/28/16 03:18:09 PM
#3216   mark these dates trop 05/28/16 02:05:25 PM
#3215   Perhaps we will see the .60s next week. R2DT 05/27/16 04:17:40 PM
#3214   Deja Vu....without the volume!!! PithicusKong 05/27/16 09:47:42 AM
#3213   Since I have not seen this flogged on PithicusKong 05/26/16 03:20:45 PM
#3212   I wish this would jump a dime to R2DT 05/26/16 01:23:08 PM
#3211   Why would you want to sell to those R2DT 05/26/16 01:15:01 PM
#3210   Ok we secured some profits. Now let's buy R2DT 05/26/16 01:04:50 PM
#3209   I hear ya buddy. Wish I had R2DT 05/26/16 12:58:53 PM
#3208   And that is comprised of manipulators, day traders, PithicusKong 05/26/16 12:35:33 PM
#3207   And sometimes "crap" comes in with the volume. R2DT 05/26/16 11:03:37 AM
#3206   Perhaps there is a bit of good news R2DT 05/26/16 10:16:45 AM
#3205   Looks promising. Hope some people are feeling R2DT 05/26/16 10:11:56 AM
#3204   THLD is seeing larger volume chunk buys this PithicusKong 05/26/16 09:56:04 AM
#3203   Pre market....two trades at one share apiece for PithicusKong 05/26/16 09:23:41 AM
#3202 was sarcasm aimed at other musings on PithicusKong 05/25/16 03:45:05 PM
#3201   Ascending to that dollar mark. R2DT 05/25/16 01:15:21 PM
#3200   Getting more attention now. R2DT 05/25/16 01:11:33 PM
#3199   Volume coming in +8.76% harmsen 05/25/16 12:56:02 PM
#3198   Since your "experts" let you know it is R2DT 05/25/16 11:52:25 AM
#3197   Wow, it is so kind hearted of you R2DT 05/25/16 11:49:16 AM
#3196   According to "experts"'s time to bail. PithicusKong 05/25/16 09:59:09 AM
#3194   you already missed two then the past week Chance 05/20/16 02:51:26 PM
#3193   so you wouldn't be booking your first flight Chance 05/20/16 02:50:59 PM
#3192   always traveling ultralight.. Chance 05/20/16 02:50:30 PM
#3191   already got on > not planning on it Chance 05/20/16 02:50:05 PM
#3190   thats 38s and bailing 44s.. Chance 05/20/16 02:49:44 PM
#3189   i posted 'Next' flight up.. Chance 05/20/16 02:49:13 PM
#3188   first flight was 31s to 37s Chance 05/20/16 02:48:55 PM
#3187   I almost think I would have more fun R2DT 05/19/16 10:21:34 AM
#3186   Wouldn't you just love to get of the R2DT 05/19/16 10:14:01 AM
#3185   LoL R2DT 05/19/16 10:08:51 AM
#3184   I would not be booking my flight just PithicusKong 05/18/16 11:15:54 AM
#3183   got a spot for the next flight up Chance 05/18/16 10:21:08 AM
#3182   Sure would like to see a good report. R2DT 05/17/16 04:07:24 PM
#3181   If you go to "Stockwatch" can enter the PithicusKong 05/17/16 02:50:11 PM
#3180   Are you sure the 10 size you are R2DT 05/17/16 02:13:20 PM
#3179   I'm not sure about the rules governing minimum R2DT 05/17/16 02:11:56 PM
#3178   I presume my questions are unanswerable! PithicusKong 05/17/16 11:10:33 AM
#3177   Is there a minimum amount of shares that PithicusKong 05/16/16 10:23:29 AM
#3176   No trust in the PPS action. This should R2DT 05/15/16 10:38:57 AM
#3175   Perhaps this will dip into the .20s and vip1999 05/14/16 08:26:52 PM
#3174   Would like to see some news of plans R2DT 05/13/16 11:29:04 AM
#3173   Soon to be bought out just for patents damondon 05/11/16 09:35:38 PM
#3172   Stagnant....if it were dead, it would not exist. PithicusKong 05/11/16 02:34:08 PM
#3171   WILL I THINK THIS STOCK IS DEAD FOR sell sell 05/11/16 05:33:11 AM
#3170   A one day flicker of green in a PithicusKong 05/10/16 10:01:26 PM
#3169   On a positive note, THLD finally closed the trop 05/07/16 06:36:00 PM