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Tenax Therapeutics, Inc. (TENX)

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Last Post: 1/22/2017 5:04:00 AM - Followers: 99 - Board type: Free - Posts Today: 0



Tenax Therapeutics ($TENX) and Levosimendan by @nvok (stocktwits.com/nvok) (twitter.com/nvok5138)
https://docs.google.com/document/d/18S6AVFjd4rHr0c9SX9iZqAtZOI9F77ciGN_KPWhH_ig

Tenax Therapeutics Corporate update - November 2016
http://cdn.irdirect.net/IR/942/1803/TENX%20Overview%20--%20Nov%202016%20.pdf


Levosimendan in Patients With Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery On Cardiopulmonary Bypass (LEVO-CTS)
https://clinicaltrials.gov/ct2/show?term=tenax&rank=2

Experimental: Levosimendan
levosimendan 0.2 µg/kg/min for first hour, followed by 0.1 µg/kg/min for an additional 23 hours

Placebo Comparator: Placebo
placebo 0.2 µg/kg/min for first hour, followed by 0.1 µg/kg/min for an additional 23 hours
Criteria

Inclusion Criteria:

  • Documented LVEF ≤35% measured by ventriculogram, echocardiogram (ECHO), nuclear scan, or MRI within 60 days before surgery.
    Scheduled or urgent 1) CABG surgery, 2)CABG with aortic valve surgery, 3) CABG with mitral valve surgery, or 4) mitral valve surgery with or without other valves
    Surgery will employ CPB pump
    Signed (by the subjects or their legally acceptable representatives) informed consent document indicating that they understand the purpose of and procedures required for the study and are willing to participate in the study

Exclusion Criteria:

  • Restrictive or obstructive cardiomyopathy, constrictive pericarditis, restrictive pericarditis, pericardial tamponade, or other conditions in which cardiac output is dependent on venous return.
    Evidence of systemic bacterial, systemic fungal, or viral infection within 72 hours before surgery.
    Dialysis at randomization (either hemodialysis, peritoneal dialysis, continuous venovenous hemofiltration, or ultrafilitration).
    Estimated glomerular filtration rate (eGFR) <30 mL/min/1.73m2.
    Weight ≥ 170 kg.
    Patients whose SBP cannot be managed to ensure SBP > 90 mmHg at initiation of study drug.
    Heart rate ≥ 120 bpm, persistent for at least 10 minutes screening and unresponsive to treatment.
    Hemoglobin < 80 g/L.
    Serum potassium < 3.5 mmol/L and > 5.5 mmol/L at baseline.
    A history of Torsades de Pointes.
    Mechanical assist device (IABP, LVAD, ECMO) in the patient at the start of surgery or pre-planned to be inserted during surgery before coming off CPB.
    Patients with aortal femoral occlusive disease that would prohibit use of IABP unless VAD or ECMO not available.
    Liver dysfunction Child Pugh Class B or C
    Patients having severely compromised immune function
    Pregnant, suspected to be pregnant, or breast-feeding.
    Received an experimental drug or used an experimental medical device in previous 30 days.
    Known allergic reaction or sensitivity to Levosimendan or excipients.
    Received commercial Levosimendan within 30 days before the planned start of study drug.
    Employees of the investigator or study center, with direct involvement in the proposed study or other studies under the direction of that investigator or study center, as well as family members of the employees or the investigator.


https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0060007


Preoperative and perioperative use of levosimendan in cardiac surgery: European expert opinion


http://www.internationaljournalofcardiology.com/article/S0167-5273%2815%2900149-7/pdf

 
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#7091  Sticky Note DD on TENX. PT 10/share. Link inside. nvok 01/09/17 09:05:06 PM
#7119   FINRA reported TENX short sales 1/20/17 only 29% tjguy 01/22/17 05:04:00 AM
#7118   FINRA reported TENX short sales 1/20/17 only 29% apollo1452 01/22/17 02:27:39 AM
#7117   Yup. Nice to see. Only have tjguy 01/22/17 12:45:09 AM
#7116   Moving back up today doesn't seem like those dave86 01/20/17 01:06:08 PM
#7115   They are gunning for the quad composite endpoint jones99 01/20/17 04:14:22 AM
#7114   the days of this dipping are a thing tjguy 01/20/17 12:34:33 AM
#7113   2.50! the days of this dipping are a dave86 01/18/17 05:20:44 PM
#7112   This is perfect before news. Superones1964 01/17/17 01:34:52 PM
#7111   I agree with the FDA only needing one dave86 01/17/17 12:21:55 PM
#7110   Need to bid a little support at 2.50 dave86 01/17/17 12:19:03 PM
#7109   Looking good here on nice volume. Betchips 01/17/17 12:10:43 PM
#7108   Nice to see it moving so well on murocman 01/17/17 11:47:08 AM
#7107   Above 2.45 resistance now lets see what it does Sugarplum 01/17/17 11:26:21 AM
#7106   This is skyrocketing today back to 2.40 already! dave86 01/17/17 09:52:39 AM
#7105   Good luck everyone with respect to upcoming data. jones99 01/16/17 05:57:02 AM
#7104   I have to wait for some unsettled shares Superones1964 01/13/17 05:07:25 PM
#7103   2.12 afterhours so its green! My avg is dave86 01/13/17 04:55:40 PM
#7102   Been all over the board today, hopeing for Superones1964 01/13/17 01:05:36 PM
#7101   Finally seeing some movement again today. dave86 01/13/17 11:01:28 AM
#7100   If phase 3 is positive one would think dave86 01/11/17 11:10:46 AM
#7099   I didn't see a price target of $10 Foreignspy 01/11/17 10:26:50 AM
#7098   Took awhile to read DD but you won Superones1964 01/11/17 08:36:29 AM
#7097   Solid DD...thank you! bUrRpPPP! 01/11/17 06:46:53 AM
#7096   They only need to be successful on one dave86 01/10/17 01:56:29 PM
#7095   I'm going to hold through data at this dave86 01/10/17 09:47:20 AM
#7094   LEVO-CTS targeted LCOS; 35 published trials already confirmed nvok 01/09/17 09:19:52 PM
#7093   LEVO-CTS top-line results in January 2017 nvok 01/09/17 09:19:31 PM
#7092   CEO and two EVP's own 4.2M shares. nvok 01/09/17 09:10:08 PM
#7091   DD on TENX. PT 10/share. Link inside. nvok 01/09/17 09:05:06 PM
#7090   2500 share but @ 2.04 after hour hoping dave86 12/03/16 05:11:44 PM
#7089   Yes, pleasant surprise before Thanksgiving, should be nice December/January. misiu143 11/23/16 11:16:25 AM
#7088   Nice move in the right direction today. Pretty penniestodimes 11/22/16 11:10:18 PM
#7087   News,...comp notify about completion of enrollment for Phase misiu143 11/18/16 02:04:44 PM
#7086   I got a position this morning as well. penniestodimes 11/18/16 01:23:29 PM
#7085   Thank you , I just don't know much here... misiu143 11/18/16 11:45:26 AM
#7084   I am glad that you did Shane Chowdhury 11/18/16 11:42:36 AM
#7083   Hi Shane C, I just bought couple thousand misiu143 11/18/16 11:35:10 AM
#7082   $10.00 stock sitting on $1.35, it's a shame. Shane Chowdhury 11/16/16 11:27:53 AM
#7081   Last doses this month, data in December 2016. Shane Chowdhury 10/28/16 11:56:46 AM
#7080   in the past 3 years this thing has ibetrading 10/27/16 04:06:40 PM
#7079   Shane, what is the base for your evaluation? In ready4 10/26/16 05:32:08 PM
#7078   It's going to be great $5.00 Shane Chowdhury 10/20/16 07:59:41 AM
#7077   This stock will reverse soon. Shane Chowdhury 10/19/16 07:14:19 PM
#7076   I think it will come up with a Shane Chowdhury 10/12/16 08:44:09 AM
#7075   I'm sure most people are reading today's update ibetrading 10/05/16 02:51:19 PM
#7074   Among the Inept, Researchers Discover, Ignorance Is Bliss blimps 05/01/16 06:02:43 AM
#7073   180 to go ! count down has started skyticket1 04/30/16 09:28:47 AM
#7072   ROTFLMAO blimps 04/28/16 08:58:40 AM
#7071   DOWN 99% in eight years. This company blimps 04/28/16 08:48:33 AM
#7070   As you can see from the post just blimps 04/28/16 08:39:51 AM
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