Rosetta Genomics, Ltd., a biotechnology company, develops microRNA-based diagnostic and therapeutic products. MicroRNAs are naturally expressed or produced using instructions encoded in DNA, and could be used in regulating protein production. The company, using its intellectual property, collaborative relationships, and microRNAs, has initiated programs to develop microRNA-based diagnostic and therapeutic products for various cancers and infectious diseases. It primarily focuses on prostate, lung, colorectal, breast, and bladder cancers. Rosetta Genomics is also developing a diagnostic test to identify the origin of the primary tumor in metastatic cancers of unknown primary site. In addition, it is collaborating with others on the development of microRNA-based therapeutic products for the treatment of liver cancer and infectious diseases. The company has collaboration and license agreements with Asuragen, Inc.; Isis Pharmaceuticals, Inc.; Hadasit Medical Research Services and Development, Ltd.; U.S. Genomics, Inc.; The Rockefeller University; Max Planck Innovation GmbH; Johns Hopkins University; Columbia University; and Tel Hashomer Medical Research Infrastructure and Services, Ltd. Rosetta Genomics was founded in 2000 and is based in Rehovot, Israel.