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Prima Biomed Ltd. (PBMD)

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Last Post: 9/27/2016 10:27:06 PM - Followers: 60 - Board type: Free - Posts Today: 0

Ticker Symbol: PBMD (PRR on the ASX - Australian Stock Exchange)

Upcoming Catalysts (8-8-16) - See below for more info on these catalysts.

Public float for ADR/Nasdaq: 64.90m (Per finviz.com 8-8-16) - (The current conversion rate between ASX:PRR Prima ordinary shares and Nasdaq ADRs is 30:1. This explains the big difference in share price.)

Per EOQ 6K - Prima Biomed reports A$20.88M in cash. (7/28/2016)

Prima Biomed acquired French biopharmaceutical company Immutep SA in late 2014. Immutep's pipeline is now starting to generate data.(Immutep was a small, private company when previous data has been released.)
http://www.marketwired.com/press-release/prima-biomed-announces-strategic-acquisition-of-immutep-sa-asx-prr-1952878.htm

Immutep's founder and Scientific and Medical Director, Professor Frédéric Triebel will join Prima as its Chief Scientific Officer. Frédéric Triebel
is best known for discovering the 
LAG3 immune control mechanism. (Prima has fully divested from their previous drug candidate, CVAC, to focus all resources on the highly prospective Immutep/LAG3 pipeline.)



More on Frédéric Triebel
https://en.wikipedia.org/wiki/Fr%C3%A9d%C3%A9ric_Triebel

More on LAG3
https://en.wikipedia.org/wiki/LAG3
 

LAG3 Drug Pipeline Information:

IMP321 -- IMP321 is soluble version of the immune checkpoint molecule LAG3, used to increase an immune response to tumours

Current Trials:
AIPAC - Currently in Phase IIb. IMP321 combined with Paclitaxel. Patients will be administered with subcutaneous doses of IMP321 on days 2 and 16 of a weekly regimen of paclitaxel, the day after their paclitaxel infusion for six months.
ClinicalTrials.gov trial link --> https://clinicaltrials.gov/ct2/show/NCT02614833?term=AIPAC&rank=1

Phase IIa results


TACTI-MEL - Currently in Phase I. Two ACTive Immunotherapeutics in melanoma will be a safety and dose finding IMP321 study. IMP321 will be combined with Merck's blockbuster drug Keytruda (Pembrolizumab).
ClinicalTrials.gov link --> https://clinicaltrials.gov/ct2/show/NCT02676869?term=tacti-mel&rank=1

Pre-clinical results from combining anti-lag3 agents (IMP321) with anti-PD-1 inhibitor therapies (Keytruda) have yielded impressive results.
http://www.onclive.com/conference-coverage/smr-2015/new-treatments-for-novel-targets-next-step-in-immuno-oncology-revolution

More information regarding TACTI-MEL from Edison:



These results have prompted Bristol Myers Squibb BMY to start a similar trial with their anti-PD-1 blockbuster drug Opdivo combinded with their LAG3 developmental drug thus validating Prima's TACTI-MEL and LAG3 which was discovered by Prima's CSO Frédéric Triebel.
https://www.mskcc.org/cancer-care/clinical-trials/14-010
https://clinicaltrials.gov/ct2/show/NCT01968109

INSIGHT - a new collaborative study investigating the intra-tumoural injection of IMP321.  The new study will explore the potential for IMP321 as an activator of dendritic cells found within solid cancer tumours.
http://finance.yahoo.com/news/prima-biomed-collaborates-investigator-sponsored-073742130.html

Collaboration with NEC Corporation and Yamaguchi University in Japan
http://finance.yahoo.com/news/prima-biomed-progresses-japanese-collaboration-120000144.html
Latest data from the collaboration published in April 2016 in the Journal Cancer Science.
Wiley Online Library - http://onlinelibrary.wiley.com/doi/10.1111/cas.12861/full

 

IMP731 - IMP731 is a depleting antibody for autoimmune disease that targets LAG3+ activated T cells. IMP731 is under development by partner Glaxo-Smith-Kline (GSK).


There is evidence, in the tuberculin-induced DTH model in primates, that a single injection of a depleting LAG-3 monoclonal antibody can prevent Th1-driven skin inflammation. (Plaque Psoriasis)

ClinicalTrials.gov link --> https://clinicaltrials.gov/ct2/show/NCT02195349?term=GSK2831781&rank=1

IMP701 - IMP701 is an anti-LAG-3 antibody which blocks LAG-3-mediated immune down-regulation. The product was originally licensed in 2012 to the American biotech company CoStim. That company was acquired by Novartis (NVS) in 2014.

http://www.streetinsider.com/Corporate+News/Prima+BioMed+%28PBMD%29+to+Receive+Phase+I+IMP701+LAG-3+Antibody-Related+Milestone+Payment+from+Novartis+%28NVS%29/10814636.html

ClinicalTrials.gov link --> https://clinicaltrials.gov/ct2/show/NCT02460224?term=lag525&rank=1

Chair of Board is Lucy Turnbull, the wife of Malcolm Turnbull who is the Prime Minister of Australia.

https://en.wikipedia.org/wiki/Lucy_Turnbull
https://en.wikipedia.org/wiki/Malcolm_Turnbull

Current trials were initiated with A$15m funding from US-based specialist healthcare investor Ridgeback Capital Investments which is run by Wayne Holman, who is widely regarded as one of the world's pre-eminent biotech investors.

Ridgeback is the largest holder of the stock at 5.5% of ASX:PRR. (Not shown on Nasdaq ADR.)



http://finance.yahoo.com/news/prima-biomed-announces-15-million-104500547.html



Adaptimmune Therapeutics stock info: http://www.finviz.com/quote.ashx?t=adap&ty=c&ta=1&p=d
Bellicum Pharmaceuticals stock info: http://www.finviz.com/quote.ashx?t=BLCM&ty=c&ta=1&p=d
Cellectis SA stock info: http://www.finviz.com/quote.ashx?t=clls&ty=c&ta=1&p=d
Medigene stock info: http://finance.yahoo.com/quote/MDGEF?ltr=1
Trillium stock info: http://www.finviz.com/quote.ashx?t=TRIL&ty=c&ta=1&p=d

Insider Ownership of PRR/PBMD can be found here in the annual report.
http://www.primabiomed.com.au/investor/annual_reports_pdf/43296kl8g00ht3.pdf?m=1456749174


Recent Analysts Upgrades:

May-12-16 Reiterated Maxim Group Buy $4 → $5
Apr-19-16 Initiated Maxim Group Buy $4
Dec-31-15 Initiated ROTH Capital Buy $6
Dec-03-15 Initiated FBR Capital Outperform $6
Oct-14-15 Initiated H.C. Wainwright Buy $3


Link to recent Analysts Reports:

http://www.primabiomed.com.au/investor/analyst_archiv.php

 

Videos:

IMP321 Mode of Action: https://www.youtube.com/watch?v=MKAdlMc25uc

Sky Business Interview with CEO Marc Voigt from 11-25-15: https://www.youtube.com/watch?v=MR44iP8DRdI

Lucy Turnbull interview from 12-26-14 shortly after the Immutep acquisition: https://www.youtube.com/watch?v=Z3_TtH--2sw

 

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PBMD News: Report of Foreign Issuer (6-k) 09/29/2016 05:14:17 PM
PBMD News: Report of Foreign Issuer (6-k) 09/06/2016 06:04:10 AM
PBMD News: Report of Foreign Issuer (6-k) 09/01/2016 06:06:58 AM
PBMD News: Report of Foreign Issuer (6-k) 08/25/2016 06:09:03 AM
PBMD News: Report of Foreign Issuer (6-k) 08/18/2016 05:15:14 PM
News News Alert: Report of Foreign Issuer (6-k) 09/29/2016 05:14:17 PM
PostSubject
#1298   This 1 ready to squeeze here soon! Watch T1aris 09/27/16 10:27:06 PM
#1297   News is coming today.Look at the order book! harmsen 09/13/16 04:12:56 AM
#1296   After hours 1.05 harmsen 09/13/16 02:48:28 AM
#1295   Thanks nohogs 09/09/16 11:23:34 AM
#1294   2:39 am Prima Biomed receives European patent grants stone840 08/25/16 03:27:11 AM
#1293   Nice work with the updates on the board. stone840 08/23/16 05:54:00 PM
#1292   That dude is the scum of the earth. nohogs 08/18/16 12:38:32 PM
#1291   someone take out that dude on stocktwits bashing spottrader 08/16/16 12:04:43 PM
#1290   iBox updated with all relevant DD. nohogs 08/08/16 01:26:26 PM
#1289   Let's get rock this baby. nohogs 07/29/16 02:39:13 PM
#1288   I will apply to be moderator. nohogs 07/29/16 02:38:34 PM
#1287   Need to get this board updated. nohogs 07/29/16 02:38:11 PM
#1286   Looking like she is ready for reversal. nohogs 07/29/16 02:37:49 PM
#1285   Prima BioMed Collaborates in Investigator Sponsored New Clinical harmsen 07/12/16 07:46:08 AM
#1284   News today! harmsen 07/12/16 06:27:45 AM
#1283   Bid 1,12 Ask 1.62 harmsen 06/22/16 04:29:20 AM
#1282   Prima BioMed Announces First Safety, Pharmacokinetics, Immuno-Monitoring Data harmsen 06/22/16 01:34:13 AM
#1281   New data released on IMP321 phase IIb that's why kvasquez 06/21/16 07:58:12 PM
#1280   Hi folks- I'm new to this board. DavenCT 06/21/16 07:51:11 PM
#1279   Thanks for the 0.96! Jess070283 05/13/16 11:24:45 AM
#1278   Holding tight. I think we should have a Jess070283 05/12/16 10:40:37 PM
#1277   Did u have me but 20k into a rightothesky 05/12/16 09:27:19 PM
#1276   * * $PBMD Video Chart 05-12-16 * * ClayTrader 05/12/16 04:47:45 PM
#1275   When the MMs got enough.Strap on your oxygen mask. bigarow 05/12/16 02:35:18 PM
#1274   MM tricks bigarow 05/12/16 02:33:21 PM
#1273   Yep. Loadem now. Short squeeze in power hour! Jess070283 05/12/16 02:32:16 PM
#1272   Yes, but something seems to be wrong as Roadtojourney 05/12/16 02:26:01 PM
#1271   People loading.Check buys & sells.http://ih.advfn.com/stock-market/NASDAQ/prima- bigarow 05/12/16 02:04:19 PM
#1270   HEre's a hint Magnum7419 05/12/16 01:28:01 PM
#1269   I'm in, lets do this! rightothesky 05/12/16 01:17:09 PM
#1268   I'm in! Looks primed and ready for lift off! Jess070283 05/12/16 12:36:44 PM
#1267   It can take up to 72 hrs for Magnum7419 05/12/16 10:52:11 AM
#1266   Their here ClearlyStocks 05/12/16 10:47:38 AM
#1265   Think again. We are on the move Roadtojourney 05/12/16 10:47:36 AM
#1264   No whales, just a selloff now. That sucks. Pitman33 05/12/16 10:15:53 AM
#1263   This is a no brainer. Should double by Magnum7419 05/12/16 09:57:41 AM
#1262   I'm loaded! ClearlyStocks 05/12/16 09:54:19 AM
#1261   Whales arrive after 10am..... hang on Magnum7419 05/12/16 09:53:55 AM
#1260   Squeeze initiated. ClearlyStocks 05/12/16 09:34:49 AM
#1259   Squeeze Tims Crew! Jess070283 05/12/16 09:23:11 AM
#1258   $1.01 seller is done. Squeeze time ClearlyStocks 05/12/16 09:20:08 AM
#1257   All you need is one whale to swallow ClearlyStocks 05/12/16 08:48:37 AM
#1256   They can effect penny stocks.. Not Nasdaq or VONGEBOB 05/12/16 08:19:46 AM
#1255   Someone is........but I dont think they have enough Magnum7419 05/12/16 08:18:00 AM
#1254   Tim Sykes crew are shorting? VONGEBOB 05/12/16 08:14:45 AM
#1253   Could get sticky.......looks like some T.S.crew sees it Magnum7419 05/12/16 08:05:47 AM
#1252   $MGT money coming into $PBMD ClearlyStocks 05/12/16 08:03:14 AM
#1251   Thanks.....I have a bid in.......hope it works as Magnum7419 05/12/16 07:55:45 AM
#1250   Could go big on his potential A$400 million news ClearlyStocks 05/12/16 07:27:54 AM
#1249   Pre-market 1.20 gap up! Nice start. Pitman33 05/12/16 07:23:55 AM
PostSubject