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Last Post: 4/17/2017 3:02:10 PM - Followers: 107 - Board type: Free - Posts Today: 0



Tenax Therapeutics Corporate update - November 2016
http://cdn.irdirect.net/IR/942/1803/TENX%20Overview%20--%20Nov%202016%20.pdf


Levosimendan in Patients With Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery On Cardiopulmonary Bypass (LEVO-CTS)
https://clinicaltrials.gov/ct2/show?term=tenax&rank=2

Experimental: Levosimendan
levosimendan 0.2 µg/kg/min for first hour, followed by 0.1 µg/kg/min for an additional 23 hours

Placebo Comparator: Placebo
placebo 0.2 µg/kg/min for first hour, followed by 0.1 µg/kg/min for an additional 23 hours
Criteria

Inclusion Criteria:

  • Documented LVEF ≤35% measured by ventriculogram, echocardiogram (ECHO), nuclear scan, or MRI within 60 days before surgery.
    Scheduled or urgent 1) CABG surgery, 2)CABG with aortic valve surgery, 3) CABG with mitral valve surgery, or 4) mitral valve surgery with or without other valves
    Surgery will employ CPB pump
    Signed (by the subjects or their legally acceptable representatives) informed consent document indicating that they understand the purpose of and procedures required for the study and are willing to participate in the study

Exclusion Criteria:

  • Restrictive or obstructive cardiomyopathy, constrictive pericarditis, restrictive pericarditis, pericardial tamponade, or other conditions in which cardiac output is dependent on venous return.
    Evidence of systemic bacterial, systemic fungal, or viral infection within 72 hours before surgery.
    Dialysis at randomization (either hemodialysis, peritoneal dialysis, continuous venovenous hemofiltration, or ultrafilitration).
    Estimated glomerular filtration rate (eGFR) <30 mL/min/1.73m2.
    Weight ≥ 170 kg.
    Patients whose SBP cannot be managed to ensure SBP > 90 mmHg at initiation of study drug.
    Heart rate ≥ 120 bpm, persistent for at least 10 minutes screening and unresponsive to treatment.
    Hemoglobin < 80 g/L.
    Serum potassium < 3.5 mmol/L and > 5.5 mmol/L at baseline.
    A history of Torsades de Pointes.
    Mechanical assist device (IABP, LVAD, ECMO) in the patient at the start of surgery or pre-planned to be inserted during surgery before coming off CPB.
    Patients with aortal femoral occlusive disease that would prohibit use of IABP unless VAD or ECMO not available.
    Liver dysfunction Child Pugh Class B or C
    Patients having severely compromised immune function
    Pregnant, suspected to be pregnant, or breast-feeding.
    Received an experimental drug or used an experimental medical device in previous 30 days.
    Known allergic reaction or sensitivity to Levosimendan or excipients.
    Received commercial Levosimendan within 30 days before the planned start of study drug.
    Employees of the investigator or study center, with direct involvement in the proposed study or other studies under the direction of that investigator or study center, as well as family members of the employees or the investigator.


https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0060007


Preoperative and perioperative use of levosimendan in cardiac surgery: European expert opinion


http://www.internationaljournalofcardiology.com/article/S0167-5273%2815%2900149-7/pdf

 
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#7495   Just when you think this has reached the Ominous 04/17/17 03:02:10 PM
#7494   Next run is in pipeline!!!€$€$ Obelax 04/10/17 11:13:14 AM
#7493   lets do this every week Walenty 04/06/17 04:28:15 PM
#7492   No gap n trap lol stock1ace1 04/06/17 11:04:01 AM
#7491   I like the volume here.Should go up more Ominous 04/06/17 10:14:45 AM
#7490   Rock & Roll mitchcoffman 04/06/17 09:41:49 AM
#7489   Seeking "strategic alternatives" reminds me of opht. Lots naturalborninvestor 04/06/17 09:12:10 AM
#7488   He did not buys 200k shares he "acquired" stock1ace1 04/06/17 06:45:31 AM
#7487   CEO bought 200K yesterday. tob999 04/06/17 05:51:59 AM
#7486   We rock & roll tomorrow! mitchcoffman 04/05/17 06:22:13 PM
#7485   Wow bought this afternoon had a sell limit rnoutlaw21 04/05/17 06:14:09 PM
#7484   I'm personally hoping for no news until the Walenty 04/04/17 03:49:38 PM
#7483   We went from 0.49 to 0.58 in 1 jones99 04/03/17 05:37:20 AM
#7482   Thanks for your reply and best of luck. MR 1955 DOUBLE DIE 04/02/17 07:00:20 AM
#7481   I'm still in. I need .62 to break Pennystomper 04/01/17 11:57:09 PM
#7480   You too mitchcoffman 04/01/17 03:03:31 PM
#7479   Lol. Gotcha. I am in at .57. Hoping MR 1955 DOUBLE DIE 04/01/17 01:36:04 PM
#7478   To the moon mitchcoffman 04/01/17 01:34:22 PM
#7477   Where do you think this goes? Or did MR 1955 DOUBLE DIE 04/01/17 12:36:34 PM
#7476   Sometime in May. The loading point was last week. Pennystomper 04/01/17 12:25:39 PM
#7475   Any clue as to when the pre nda Walenty 03/29/17 11:57:44 AM
#7474   Any news would be nice mitchcoffman 03/27/17 11:24:02 AM
#7473   With 23 million in cash? Please do explain? Pennystomper 03/24/17 11:16:04 AM
#7472   TENX is about to go bankrupt. FightingBack 03/24/17 07:47:25 AM
#7471   I'm now down 5 cents. Any good news Pennystomper 03/23/17 03:13:02 PM
#7470   They need to figure something out fast, pump mitchcoffman 03/23/17 12:20:26 PM
#7469   It regretable if he gets a bonus for Masala 03/23/17 09:48:20 AM
#7468   I also hope to hear his resignation. Do biscotte 03/23/17 06:36:28 AM
#7467   The CEO needs to resign. For him to Masala 03/22/17 05:34:59 PM
#7466   Personaly I feel as though they purposely made Pennystomper 03/22/17 11:58:36 AM
#7465   And you heard that where? Ominous 03/21/17 10:24:37 PM
#7464   Is it true tenx is looking at a tk88 03/21/17 01:43:50 PM
#7463   enough cash through mid 2018 plus file an NOT-BUYING-IN-IT 03/21/17 07:10:59 AM
#7462   going to $1.00 + premarket...conference call NOT-BUYING-IN-IT 03/21/17 07:10:04 AM
#7461   21.9 million in cash as of December 31 2016 mitchcoffman 03/21/17 06:15:42 AM
#7460   Who's going to watch the presentation at 8:30? mitchcoffman 03/21/17 05:43:38 AM
#7459   This is out. We will hear about the Pennystomper 03/19/17 12:21:48 PM
#7457   Never mind this thing flopped again..I guess it's Masala 03/19/17 08:48:39 AM
#7456   Will this one trick pony be acquired Masala 03/17/17 03:17:29 PM
#7454   Wasn't a total failure-- "levosimendan was found to Pennystomper 03/17/17 11:24:06 AM
#7453   " Dirigeables " was right. Mea culpa . biscotte 03/17/17 06:10:35 AM
#7452   Oops maybe back to $.41 I'm long Masala 03/12/17 04:37:49 PM
#7451   I'm also hoping for .85 to .90. porgyrusty 03/12/17 04:37:47 PM
#7450   Gal gonna fill abazaba375 03/12/17 04:11:05 PM
#7449   Lots of downside potential. This is as risky Pennystomper 03/11/17 02:07:49 PM
#7448   What's the down side? Thanks MR 1955 DOUBLE DIE 03/11/17 12:08:43 PM
#7447   I'm looking for an early out in the Pennystomper 03/10/17 09:45:56 PM
#7446   Ok, where we headed next week? Just wanted Nelry 03/10/17 06:19:12 PM
#7445   Anyone concerned for the release of the 90 MR 1955 DOUBLE DIE 03/10/17 06:15:06 PM
#7444   Lunchtime dip over time to rip past .80 abazaba375 03/10/17 01:23:48 PM
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