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Tenax Therapeutics, Inc. (TENX)

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Last Post: 8/1/2017 9:43:51 AM - Followers: 111 - Board type: Free - Posts Today: 0



Tenax Therapeutics Corporate update - November 2016
http://cdn.irdirect.net/IR/942/1803/TENX%20Overview%20--%20Nov%202016%20.pdf


Levosimendan in Patients With Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery On Cardiopulmonary Bypass (LEVO-CTS)
https://clinicaltrials.gov/ct2/show?term=tenax&rank=2

Experimental: Levosimendan
levosimendan 0.2 µg/kg/min for first hour, followed by 0.1 µg/kg/min for an additional 23 hours

Placebo Comparator: Placebo
placebo 0.2 µg/kg/min for first hour, followed by 0.1 µg/kg/min for an additional 23 hours
Criteria

Inclusion Criteria:

  • Documented LVEF ≤35% measured by ventriculogram, echocardiogram (ECHO), nuclear scan, or MRI within 60 days before surgery.
    Scheduled or urgent 1) CABG surgery, 2)CABG with aortic valve surgery, 3) CABG with mitral valve surgery, or 4) mitral valve surgery with or without other valves
    Surgery will employ CPB pump
    Signed (by the subjects or their legally acceptable representatives) informed consent document indicating that they understand the purpose of and procedures required for the study and are willing to participate in the study

Exclusion Criteria:

  • Restrictive or obstructive cardiomyopathy, constrictive pericarditis, restrictive pericarditis, pericardial tamponade, or other conditions in which cardiac output is dependent on venous return.
    Evidence of systemic bacterial, systemic fungal, or viral infection within 72 hours before surgery.
    Dialysis at randomization (either hemodialysis, peritoneal dialysis, continuous venovenous hemofiltration, or ultrafilitration).
    Estimated glomerular filtration rate (eGFR) <30 mL/min/1.73m2.
    Weight ≥ 170 kg.
    Patients whose SBP cannot be managed to ensure SBP > 90 mmHg at initiation of study drug.
    Heart rate ≥ 120 bpm, persistent for at least 10 minutes screening and unresponsive to treatment.
    Hemoglobin < 80 g/L.
    Serum potassium < 3.5 mmol/L and > 5.5 mmol/L at baseline.
    A history of Torsades de Pointes.
    Mechanical assist device (IABP, LVAD, ECMO) in the patient at the start of surgery or pre-planned to be inserted during surgery before coming off CPB.
    Patients with aortal femoral occlusive disease that would prohibit use of IABP unless VAD or ECMO not available.
    Liver dysfunction Child Pugh Class B or C
    Patients having severely compromised immune function
    Pregnant, suspected to be pregnant, or breast-feeding.
    Received an experimental drug or used an experimental medical device in previous 30 days.
    Known allergic reaction or sensitivity to Levosimendan or excipients.
    Received commercial Levosimendan within 30 days before the planned start of study drug.
    Employees of the investigator or study center, with direct involvement in the proposed study or other studies under the direction of that investigator or study center, as well as family members of the employees or the investigator.


https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0060007


Preoperative and perioperative use of levosimendan in cardiac surgery: European expert opinion


http://www.internationaljournalofcardiology.com/article/S0167-5273%2815%2900149-7/pdf

 
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PostSubject
#7550   Took a big hit RisingMT 08/01/17 09:43:51 AM
#7549   Same old story...... FDA rejects the data from blimps 07/29/17 06:52:59 PM
#7548   10-4 thx bud Tarheel-Blue 07/20/17 08:50:38 PM
#7547   go to stock twits.com. A lot more DR. Brule 07/20/17 08:04:46 PM
#7546   go to stock twits.com. A lot more DR. Brule 07/20/17 08:04:46 PM
#7545   Not a bad day at all here, volume Tarheel-Blue 07/20/17 04:15:52 PM
#7544   Beast mode, lookin good here! Tarheel-Blue 07/20/17 10:03:14 AM
#7543   TENX volume @.77 TradeNaked 07/20/17 10:00:45 AM
#7542   Bid higher than last trade, here comes .70's Tarheel-Blue 07/19/17 03:52:23 PM
#7541   Si Señor TradeNaked 07/19/17 03:31:38 PM
#7540   $TENX ready for dolla land. Technicals look primed Tarheel-Blue 07/18/17 10:16:19 AM
#7539   Do someone crazy... do somethin crazy...XD Grizmoney22 07/18/17 10:15:57 AM
#7538   Well then....... Let's see. blimps 07/17/17 02:51:14 AM
#7537   If the fda won't approve it . We Oren1976 07/17/17 01:48:27 AM
#7536   You are not looking at the pattern. blimps 07/16/17 04:15:31 PM
#7535   I see so they have a very bad Oren1976 07/16/17 02:38:33 PM
#7534   The easy answer to your question is............ This blimps 07/15/17 06:04:02 PM
#7533   Just one small thing can u please show Oren1976 07/15/17 04:10:19 PM
#7532   OK, I think it is time to take blimps 07/13/17 05:41:23 AM
#7531   ...and up she goes again! scottm2753 07/07/17 02:45:36 PM
#7530   Down she goes.....wtf Locke1 07/07/17 01:04:56 PM
#7529   The weekly chart shows strong bullish trend TraderUsa 07/01/17 07:27:04 PM
#7528   First target $1-$1.30 TraderUsa 07/01/17 07:26:24 PM
#7527   TENX CNN Money said a median target $2.5 TraderUsa 07/01/17 05:08:42 PM
#7526   TENX Stockinvest said: STRONG BUY CANDIDATE TraderUsa 07/01/17 05:06:15 PM
#7525   TENX 3 Reasons to buy Tenax Therapeutics TraderUsa 07/01/17 04:49:47 PM
#7524   TENX Americabulls.com said Stay Long TraderUsa 07/01/17 04:48:27 PM
#7523   TENX Tenax Therapeutics Barchart Opinion : 80% Buy TraderUsa 07/01/17 04:38:40 PM
#7522   https://pbs.twimg.com/media/DDqZY9IW0AAMzv1.jpg bell345 07/01/17 02:36:20 PM
#7521   Sorry, what does that mean? RisingMT 07/01/17 02:33:26 PM
#7520   Chat rooms are trading it. bell345 07/01/17 02:05:58 PM
#7519   * * $TENX Video Chart 06-30-17 * * ClayTrader 06/30/17 05:06:09 PM
#7518   What the hell? Is there news or something? RisingMT 06/30/17 04:29:44 PM
#7517   Another HUGE volume day today!! chemist72 06/30/17 01:06:33 PM
#7516   Go over to Stocktwits.com. It gets much DR. Brule 06/29/17 12:41:28 PM
#7515   Why is this stock not getting more attention... Grizmoney22 06/29/17 11:32:51 AM
#7514   Anyone see a resemblance between $OCRX and $TENX??? Grizmoney22 06/21/17 04:16:48 PM
#7513   Volume up ~400% too! :) chemist72 06/21/17 03:56:43 PM
#7512   Doing well today! RisingMT 06/21/17 03:23:01 PM
#7511   Subset Group 73% reduction in Mortality shurtha2000 06/13/17 10:30:48 AM
#7510   Just a wake up call. This issue blimps 06/10/17 09:58:13 AM
#7507   I hope you are not serious.......... This blimps 06/09/17 10:50:53 AM
#7506   Finally starting to turn around. DR. Brule 06/02/17 06:32:54 AM
#7505   Starting to show some strength here DR. Brule 06/01/17 09:41:38 AM
#7504   * * $TENX Video Chart 05-17-17 * * ClayTrader 05/17/17 05:10:19 PM
#7503   Seems like there is no bottom,keeps sliding down Ominous 05/16/17 09:56:08 AM
#7502   Geez no way to argue against you. MR 1955 DOUBLE DIE 05/09/17 03:21:22 PM
#7500   OK, I think it is time to take blimps 05/05/17 04:10:59 PM
#7499   January 1st of this year this was at blimps 05/05/17 04:04:05 PM
#7498   DOWN 99% in eight years. This company has blimps 05/05/17 04:00:53 PM
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