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Tenax Therapeutics, Inc. (TENX)

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Last Post: 2/22/2017 9:11:17 AM - Followers: 114 - Board type: Free - Posts Today: 0



Tenax Therapeutics Corporate update - November 2016
http://cdn.irdirect.net/IR/942/1803/TENX%20Overview%20--%20Nov%202016%20.pdf


Levosimendan in Patients With Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery On Cardiopulmonary Bypass (LEVO-CTS)
https://clinicaltrials.gov/ct2/show?term=tenax&rank=2

Experimental: Levosimendan
levosimendan 0.2 µg/kg/min for first hour, followed by 0.1 µg/kg/min for an additional 23 hours

Placebo Comparator: Placebo
placebo 0.2 µg/kg/min for first hour, followed by 0.1 µg/kg/min for an additional 23 hours
Criteria

Inclusion Criteria:

  • Documented LVEF ≤35% measured by ventriculogram, echocardiogram (ECHO), nuclear scan, or MRI within 60 days before surgery.
    Scheduled or urgent 1) CABG surgery, 2)CABG with aortic valve surgery, 3) CABG with mitral valve surgery, or 4) mitral valve surgery with or without other valves
    Surgery will employ CPB pump
    Signed (by the subjects or their legally acceptable representatives) informed consent document indicating that they understand the purpose of and procedures required for the study and are willing to participate in the study

Exclusion Criteria:

  • Restrictive or obstructive cardiomyopathy, constrictive pericarditis, restrictive pericarditis, pericardial tamponade, or other conditions in which cardiac output is dependent on venous return.
    Evidence of systemic bacterial, systemic fungal, or viral infection within 72 hours before surgery.
    Dialysis at randomization (either hemodialysis, peritoneal dialysis, continuous venovenous hemofiltration, or ultrafilitration).
    Estimated glomerular filtration rate (eGFR) <30 mL/min/1.73m2.
    Weight ≥ 170 kg.
    Patients whose SBP cannot be managed to ensure SBP > 90 mmHg at initiation of study drug.
    Heart rate ≥ 120 bpm, persistent for at least 10 minutes screening and unresponsive to treatment.
    Hemoglobin < 80 g/L.
    Serum potassium < 3.5 mmol/L and > 5.5 mmol/L at baseline.
    A history of Torsades de Pointes.
    Mechanical assist device (IABP, LVAD, ECMO) in the patient at the start of surgery or pre-planned to be inserted during surgery before coming off CPB.
    Patients with aortal femoral occlusive disease that would prohibit use of IABP unless VAD or ECMO not available.
    Liver dysfunction Child Pugh Class B or C
    Patients having severely compromised immune function
    Pregnant, suspected to be pregnant, or breast-feeding.
    Received an experimental drug or used an experimental medical device in previous 30 days.
    Known allergic reaction or sensitivity to Levosimendan or excipients.
    Received commercial Levosimendan within 30 days before the planned start of study drug.
    Employees of the investigator or study center, with direct involvement in the proposed study or other studies under the direction of that investigator or study center, as well as family members of the employees or the investigator.


https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0060007


Preoperative and perioperative use of levosimendan in cardiac surgery: European expert opinion


http://www.internationaljournalofcardiology.com/article/S0167-5273%2815%2900149-7/pdf

 
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#7091  Sticky Note DD on TENX. PT 10/share. Link inside. nvok 01/09/17 09:05:06 PM
#7399   Up .05 in pre-market on 22,000 volume. duderaja 02/22/17 09:11:17 AM
#7398   Nice stair step forming. duderaja 02/21/17 01:33:49 PM
#7397   Power hour should be fun today. Plenty Jethrobodean 02/21/17 01:23:56 PM
#7396   $CHART TECHNICALS CUP AND HANDLE! jiminey 02/21/17 12:59:49 PM
#7395   Now's the time to get in the train... ursa 02/21/17 12:41:06 PM
#7394   About to run hard now DR. Brule 02/21/17 12:35:50 PM
#7393   $456,000 trade just went through...Geez DR. Brule 02/21/17 09:35:48 AM
#7392   Stop with your radiation! We have at least biscotte 02/20/17 02:56:22 PM
#7391   Thank you. I am learning more and more MR 1955 DOUBLE DIE 02/19/17 09:32:20 PM
#7390   Yes I'm aware of that,a notice on the Masala 02/19/17 10:16:36 AM
#7389   Saw this posted on Stocktwits. https://twitter.com/vanjohn10/status/8330731317 Canoepaddler 02/18/17 09:43:01 PM
#7388   Apologize for any confusion. They own 500,000 shares. Canoepaddler 02/18/17 09:17:44 PM
#7387   can't seem to find link. Could you please kld2 02/18/17 09:03:16 PM
#7386   After notice they will be given 6 months duderaja 02/18/17 05:39:35 PM
#7385   Delisting is along drawn process, 180 days away Masala 02/18/17 05:01:51 PM
#7384   Agreed. Nice job. MR 1955 DOUBLE DIE 02/17/17 09:23:01 PM
#7383   Wow. I know of others but not that MR 1955 DOUBLE DIE 02/17/17 09:22:03 PM
#7382   Yep. Filing came this week. Point 72 bought Canoepaddler 02/17/17 08:37:54 PM
#7381   AQXP is an example. It went to $1s Canoepaddler 02/17/17 08:29:11 PM
#7380   Not a biggie. If FDA likes the data Canoepaddler 02/17/17 08:27:38 PM
#7379   Present price $ .75 - no broker would blimps 02/17/17 07:10:15 PM
#7378   I'm sorry but they do.. they are representations jiminey 02/17/17 07:09:03 PM
#7377   Charts of a failing penny stock mean nothing. blimps 02/17/17 07:07:41 PM
#7376   previous stock price = +$2.00, i know my jiminey 02/17/17 07:06:52 PM
#7375   Name a broker that allows shorting of a blimps 02/17/17 07:05:42 PM
#7374   View the $CHART. REVERSAL IN EFFECT jiminey 02/17/17 07:04:20 PM
#7373   because he's shorting the stock. jiminey 02/17/17 06:59:06 PM
#7372   Look for a reverse split. That is blimps 02/17/17 05:39:08 PM
#7371   Wrong, the trial was a failure and the blimps 02/17/17 05:37:23 PM
#7370   Lies on your part. The drug met several MR 1955 DOUBLE DIE 02/17/17 05:33:03 PM
#7369   They have less than 2 weeks to get ibetrading 02/17/17 05:13:42 PM
#7368   Why "I" care. I knew the founders blimps 02/17/17 03:11:17 PM
#7367   So why in the hell do you post DR. Brule 02/17/17 03:00:36 PM
#7366   No need to wait for anything. It blimps 02/17/17 02:36:11 PM
#7365   Wait March , 20 . Ok ? biscotte 02/17/17 02:01:17 PM
#7364   You sir, are incorrect. The company's ONLY blimps 02/17/17 01:19:01 PM
#7363   @ Dirigeables . biscotte 02/17/17 12:50:23 PM
#7362   Let's just look at the last 2 reverse blimps 02/17/17 10:21:10 AM
#7361   Does anyone have a guess on how long blimps 02/17/17 10:10:14 AM
#7360   WOW, we were at $2.18 on January 1st. blimps 02/17/17 10:01:54 AM
#7359   Agreed. Best to you. MR 1955 DOUBLE DIE 02/16/17 10:19:43 PM
#7358   Picked some up here today. $1+ soon in Canoepaddler 02/16/17 08:43:35 PM
#7357   Technically he's not wrong he just said it's mylar23 02/16/17 06:33:34 PM
#7356   looks like she wants to run to 1. ursa 02/16/17 03:53:28 PM
#7355   Or NOT. LOL blimps 02/16/17 03:47:22 PM
#7354   Volume spiking. Power hour could get interesting. Jethrobodean 02/16/17 02:53:02 PM
#7353   Thank you. $$$ MR 1955 DOUBLE DIE 02/15/17 04:20:35 PM
#7352   Pump and dump. Pump and dump my blimps 02/15/17 03:40:37 PM
#7351   Nonsense. They are selling NEW shares into blimps 02/15/17 03:38:50 PM
#7350   She is gonna close strong and open at 0.8 ursa 02/15/17 03:22:56 PM
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