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Mast Therapeutics, Inc. (MSTX)

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Mast Therapeutics
 We are a publicly traded biopharmaceutical company headquartered in San Diego, California.

We are leveraging the MAST (Molecular Adhesion and Sealant Technology) platform, derived from over two decades of clinical, nonclinical and manufacturing experience with purified and non-purified poloxamers, to develop MST-188, our lead product candidate, for serious or life-threatening diseases with significant unmet needs.  Webcast from Cowen Healthcare Conference 03/03/14  Piper Jaffray Healthcare Conference 12/03/13 : 30 minute audio presentation by CEO B. Culley  NEW    12th Annual Bio-Investor Conference 10/08/13: 32 page PDF NEW 
Blog Update from CEO B. Culley 12/12/13  NEW  Data From Proof of Concept Study in Heart Failure 

A service of the U.S. National Institutes of Health


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Evaluation of Purified Poloxamer 188 in Children in Crisis (EPIC)

This study is currently recruiting participants.
Verified July 2013 by Mast Therapeutics, Inc.
Mast Therapeutics, Inc.
Information provided by (Responsible Party):
Mast Therapeutics, Inc. Identifier:
First received: November 27, 2012
Last updated: July 22, 2013
Last verified: July 2013

The purpose of this study is to evaluate whether ANX-188 can reduce the duration of vaso-occlusive crisis (VOC) in subjects with sickle cell disease. The study will also evaluate whether ANX-188 can reduce the frequency of rehospitalization of subjects due to a recurrence of VOC. Additionally, this study will compare the development of acute chest syndrome during VOC in subjects who receive ANX-188 to those who do not receive ANX-188.

Condition Intervention Phase
Vaso-occlusive Crisis
Sickle Cell Disease
Drug: ANX-188
Drug: Saline
Phase 3
Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator)
Primary Purpose: Treatment
Official Title: Evaluation of Purified Poloxamer 188 in Children in Crisis (EPIC): A Phase 3 Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Trial of ANX-188 (Purified Poloxamer 188) Injection in Children With Sickle Cell Disease Experiencing Vaso Occlusive Crisis
Resource links provided by NLM:
Further study details as provided by Mast Therapeutics, Inc.:
Primary Outcome Measures:
  • Reduction of the duration of vaso occlusive crisis (VOC) in subjects with sickle cell disease. [ Time Frame: Study participants will be followed for the duration of hospital stay, an expected average of 4 days ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Re-hospitalization rate for VOC [ Time Frame: Hospital discharge to 14 days post-discharge ] [ Designated as safety issue: No ]
    Occurence of acute chest syndrome [ Time Frame: Randomization to 120 hours after randomization ] [ Designated as safety issue: No ]
Estimated Enrollment: 388
Study Start Date: May 2013
Estimated Primary Completion Date: December 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: ANX-188
ANX-188 injection administered as a continuous infusion 100 mg/kg for 1 hour followed by 30 mg/kg/hr for up to 48 hours.
Drug: ANX-188
Placebo Comparator: Saline
Saline administered as a continuous infusion for up to 49 hours
Drug: Saline


Please refer to this study by its identifier: NCT01737814

Contact: Mast Therapeutics Call Center 1-888-965-1238  

Responsible Party: Mast Therapeutics, Inc. Identifier: NCT01737814     History of Changes
Other Study ID Numbers: ANX-188-01
Study First Received: November 27, 2012
Last Updated: July 22, 2013
Health Authority: United States: Food and Drug Administration

Keywords provided by Mast Therapeutics, Inc.:
sickle cell disease
vaso-occlusive crisis

Additional relevant MeSH terms:
Anemia, Sickle Cell
Anemia, Hemolytic, Congenital
Anemia, Hemolytic
Hematologic Diseases
Genetic Diseases, Inborn processed this record on July 25, 2013





MST-188 (lead product candidate)

MST-188 (purified poloxamer 188) is an investigational agent that has potential to reduce ischemic tissue injury and end-organ damage by restoring microvascular function, which is compromised in a wide range of serious and life-threatening diseases and conditions. We initially are developing MST-188 as a treatment for complications arising from sickle cell disease.



Exelbine™, or ANX-530 (vinorelbine injectable emulsion), is a novel emulsion formulation of the chemotherapy drug vinorelbine (Navelbine®). We are seeking a partner or outside investor to continue development of the Exelbine program.


ANX-514 (docetaxel for injectable emulsion) is a novel, detergent-free emulsion formulation of the chemotherapy drug docetaxel. We are seeking a partner or outside investor to continue development of the ANX-514 program.

2013 Activities

Event Timing

Initiate tQT/QTc Study Completed

Secure Orphan Designation for MST-188 for SCD in EU Completed

Activate First Site in Phase 3 Study Completed

File New Patent Applications Completed

Dose First Subject in Phase 3 Study Completed

Report data from tQT/QTc Study Q3 Completed and Primary Endpoints Met

Request Orphan Designation for MST-188 for ALI in U.S. Q3 Completed and Designation Granted By FDA

Initiate Nonclinical Proof-of-Concept Study in Heart Failure Q3 Completed and POC Data to be released Q1 '14

2014 Activities

Event Timing

Present Data From Nonclinical Proof-of-Concept Study In Heart Failure  Q1 '14  Data Released 01/06/14'Showed Significant Statistical Improvement"

Initiate Phase 2 Study in ALI Q1 '14 Initiated

Outcome of review of application for Unique Name Designation For Purified Poloxamer 188 From U.S. Adopted Names Counsel Q1 '14 Granted and Named VEPOLOXAMER

Open First Ex-U.S. Clinical Sites in Phase 3 Trial Q1 '14. Initiated and On Schedule

Submit Abstract with Heart Failure Study Biomarker Data to Major Medical Conference Q2 '14

Request Orphan Designation for ALI in EU Q2 '14  Application Submitted

Initiate Nonclinical POC Study in Stroke Q2 '14 Study Initiated

Initiate EPIC Sub-Study Q2 '14 Initiated On Schedule 06/14/14

Report Results from Phase 2 Study of AIR001 in PAH Q3 '14 Positive Top line Data released 9/8/14

Initiate study with Dept of Defense: MST-188 Resuscitation from major trauma '14 CRADA with US Military Initiated Q3 '14

Receive protocol from FDA for Phase 2 Heart Failure Study Q4'14


Video of Management of Mast Therapeutics $MSTX speaking about MST-188 for Sickle Cell Disease ,orphan drug

Schedule 13D and 13G filings submitted since 03/31/2013

  Filing Company Date of
Total Reported
Shares Owned
Shares Reported
on 13F
  Baker Bros LLC 03/31/14 3,000,000 3,000,000
SC 13G SABBY MANAGEMENT, LLC 11/07/2014 8,854,300 8,854,300
SC 13G FRANKLIN RESOURCES INC 07/10/2013 10,987,000 12,000,000
Reported via Event Date Name Ticker Shares * Change % of Portfolio
13F MPM Asset Management     MSTX 2,551,851    
13F Vanguard Group     MSTX 2,810,791    




Contact Information

P: 858-552-0866    F: 858-552-0876
General Inquiries

Investor Relations Contact

Business Development Contact

Careers Contact




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Current Price
Bid Ask Day's Range
ANX News: Mast Therapeutics Initiates Sub-Study Within Phase 3 EPIC Trial 06/16/2014 08:00:00 AM
News News Alert: Mast Therapeutics To Present At The 26th Annual Piper Jaffray Healthcare Conference On December 3rd 11/26/2014 08:00:00 AM
#12417   After flipping out at .60 a few months RNsidersbuying 11/25/14 12:21:52 PM
#12416   Its stuck in the bloody .40's now, but JDLAXXE 11/25/14 07:49:12 AM
#12415   11/21/14-9:30a lecorb 11/24/14 09:13:21 AM
#12414   Hard to move above .50 with past offering. pray 11/24/14 08:14:38 AM
#12413   I'm holding for next spike. 1's or more JDLAXXE 11/22/14 09:47:01 PM
#12412   Lecorb would you mind linking the Cowen initiation laker2000 11/21/14 06:17:33 PM
#12411   Two analysts in four days, buy with a lecorb 11/21/14 04:42:54 PM
#12410   CEO Golf Lessons ...... pray 11/21/14 04:28:30 PM
#12409   Nice sell just now....probably the company tapping the TriggerPuller79 11/21/14 10:33:22 AM
#12408   Mast Therapeutics Started at Outperform by Cowen MSTX lecorb 11/21/14 09:55:23 AM
#12407   Yeah baby yeah !!! Go MSTX. The Bread Man 11/21/14 09:06:14 AM
#12406   Interested to see where she opens following last Rhodey Red 11/21/14 08:09:06 AM
#12405   After Hour:11,500 shares buy in ask @.50 16:27:36 lecorb 11/20/14 04:52:51 PM
#12404   Maybe today is the day we go over The Bread Man 11/20/14 10:26:01 AM
#12403   Nice News in with 21.000 shares,good luck and harmsen 11/19/14 02:41:46 PM
#12402   link for Highlander release laker2000 11/19/14 01:32:44 PM
#12401   Mew Coverage, Highlander iniates coverage on Mstx with laker2000 11/19/14 01:32:15 PM
#12400   In level two, upgrade from sell in red, lecorb 11/19/14 08:59:52 AM
#12399   Here's the press release: Rhodey Red 11/19/14 08:40:23 AM
#12398   Heart Failure data release via presentation poster for Rhodey Red 11/19/14 08:33:25 AM
#12397   I beleive within a few months MSTX will JDLAXXE 11/18/14 10:51:45 PM
#12396   Well my son is only 18 months so Rhodey Red 11/18/14 09:54:44 PM
#12395   In level two, upgrade from sell in red, lecorb 11/18/14 07:51:53 PM
#12394   When this started going up last December I pray 11/18/14 08:38:55 AM
#12393   Another analyst putting out buy on MSTX. JDLAXXE 11/18/14 12:27:32 AM
#12392   This quarter actually. Waiting on FDA protocol for Rhodey Red 11/17/14 01:28:07 PM
#12391   When will be next major catalyst? Next year? wallstreetbuyer 11/17/14 10:21:57 AM
#12390   Canaccord Genuity Initiates Mast Therapeutics With Buy, $3.00 lecorb 11/17/14 09:12:52 AM
#12389 Cicant 11/17/14 09:07:40 AM
#12388   So are we on our way here or The Bread Man 11/13/14 03:46:58 PM
#12387   "whale wisdom" hun? Its your source. JDLAXXE 11/13/14 12:45:59 AM
#12386   Franklin reported position 11,946,100.......Vanguard Gro reported increased pos. laker2000 11/12/14 03:44:21 PM
#12385   Is that in an institutional filing? Can you JDLAXXE 11/12/14 01:00:31 AM
#12384   I was super happy to buy some °MSTX° JDLAXXE 11/12/14 12:53:49 AM
#12383   Had a further discussion with thing they laker2000 11/07/14 04:22:54 PM
#12382   Sabby.... looks like it holds sub. more share laker2000 11/07/14 03:31:02 PM
#12381   Inst. report...Ancora Advisors added to holdings 150,000 up laker2000 11/07/14 12:46:05 PM
#12380   Also queried the financing with some frustration and laker2000 11/07/14 11:32:24 AM
#12379   I have never seen a company having two pray 11/07/14 12:29:36 AM
#12378   The gist of IR response in two emails Rhodey Red 11/06/14 08:31:30 PM
#12377   Cash 60.000.000 for Mast Therapeutics harmsen 11/06/14 03:37:46 PM
#12376   Any thoughts on why with 40 million in pray 11/06/14 09:32:25 AM
#12375   GUESS HE WANTS IT DOWN TO .01 CENT pray 11/05/14 09:53:59 PM
#12374   Can anyone tell me why, after an offering pray 11/05/14 09:52:19 PM
#12373   More dilution...awesome...another offering just announced TriggerPuller79 11/05/14 06:14:55 PM
#12372   Creeping back down to all time low. Never pray 11/04/14 08:34:03 PM
#12371   Appreciate the correction. pray 10/31/14 05:48:28 PM
#12370   Wrong drug and study. It was MST-188's application at14tao 10/31/14 12:28:26 PM
#12369   Markets up almost 400 points in last 3 pray 10/31/14 11:13:54 AM
#12368   If they could some how, anyway use some pray 10/31/14 08:54:53 AM