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Idera Pharmaceuticals, Inc. (IDRA)

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Moderator: No Moderator Seel, Black sunshine
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Last Post: 9/2/2015 8:51:14 PM - Followers: 149 - Board type: Free - Posts Today: 0

The Company has created DNA-based compounds that in preclinical studies act as antagonists of TLR7 and TLR9, such as IMO-3100, or as antagonists of TLRs 7, 8, and 9, such as IMO-8400. The Company is developing IMO-3100, an antagonist of TLR7 and TLR9, for the treatment of psoriasis. It has selected IMO-8400, an antagonist of TLRs 7, 8, and 9, for development in the treatment of autoimmune diseases, with lupus as the initial disease indication. IMO-2055, a TLR9 agonist, is its lead drug candidate for the treatment of cancer. Clinical trials of IMO-2055 completed by the Company or by Merck KGaA include four Phase I clinical trials, of which two were in healthy subjects and two were in refractory cancer patients, and one Phase II clinical trial. The Phase II clinical trial was a monotherapy trial of IMO-2055 in patients with metastatic or recurrent clear cell renal cancer.

In preclinical animal models, the Company TLR7, 8, and 9 agonists have shown adjuvant activity when combined with various types of antigens. It has designed and created a new class of molecules to inhibit gene expression. These gene silencing oligonucleotides, which it refer to as GSOs, are nucleic acid-based and represent a novel approach to selectively, silence gene expression. It is actively engaged in preclinical research with its GSOs that is designed to explore their potential as research reagents and therapeutic agents. In addition to the Company’s clinical programs in autoimmune and inflammatory diseases and in cancer, it has identified TLR drug candidates for applications in the treatment of infectious diseases, respiratory diseases and hematological malignancies, and TLR3 agonists for use as vaccine adjuvants.

IMO-2125, a synthetic DNA-based TLR9 agonist, is its lead candidate for the treatment of chronic hepatitis C virus (HCV), infection. The Company conducted two Phase I clinical trials of IMO-2125 in patients with chronic HCV infection, one in patients with HCV who had not responded to prior treatment and one in combination with ribavirin, an antiviral medication approved for use in combination with interferon-alpha in the treatment of HCV infection, in treatment-naive patients with genotype 1 chronic HCV infection. In addition to the use of TLR9 agonists in oncology applications, it selected IMO-4200 as a lead TLR7 and TLR8 agonist candidate for the treatment of hematological cancers. Its TLR9 agonists are designed to induce immune responses that could be useful in restoring immune system balance. IMO-2134 is its lead TLR9 agonist for asthma and allergies. In addition to use of TLR7, 8, and 9 agonists as vaccine adjuvants, it also has created TLR3 agonists for potential use as vaccine adjuvants.

The Company competes with Dynavax Technologies Corporation, GlaxoSmithKline plc., Pfizer, Inc., VentiRx Pharmaceuticals., Novartis, Dynavax Technologies Corporation, VaxInnate, Inc., Intercell AG, Cytos Biotechnology AG and Celldex Therapeutics, Inc.



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IDRA News: Securities Registration: Employee Benefit Plan (s-8) 08/06/2015 06:52:12 AM
IDRA News: Securities Registration: Employee Benefit Plan (s-8) 08/06/2015 06:51:31 AM
IDRA News: Quarterly Report (10-q) 08/06/2015 06:43:00 AM
IDRA News: Biotechnology Stocks Technical Data -- Keryx Biopharma, Idera Pharma, Synthetic Biologics, OvaScience and Infinity Pharma 08/05/2015 09:10:00 AM
IDRA News: Statement of Changes in Beneficial Ownership (4) 07/06/2015 06:46:41 PM
#718  Sticky Note Hi Seel. Let me assure you that despite ajsmith 03/09/14 01:35:35 AM
#1974   Strong finish,..trend? Canoepaddler 09/02/15 08:51:14 PM
#1973   That's the way I see it too ;-) TheHound 09/01/15 10:24:56 PM
#1972   Maybe we got a flush today on the Canoepaddler 09/01/15 07:13:35 PM
#1971   Taking pieces. Over paid on this piece today. Citrati 09/01/15 06:25:48 PM
#1970   You are in accumulation mode here and elsewhere Seel 09/01/15 06:09:06 PM
#1969   Added some 2.92 stock. Citrati 09/01/15 10:21:03 AM
#1968   Short interest, 16 days to cover. Bread Man 09/01/15 07:26:18 AM
#1966   I more than doubled my position here today. Canoepaddler 08/31/15 08:07:55 PM
#1965   More smiles coming for the faithful. Citrati 08/31/15 01:36:18 PM
#1964   I had a feeling once we break $3.00 redharocosmo 08/31/15 10:42:05 AM
#1963   Beast mode!!! Bread Man 08/31/15 09:56:44 AM
#1962   ET, the fat redheaded boss said this was TheHound 08/30/15 05:07:48 PM
#1961   LOL, no kidding. How about that $1 prediction Citrati 08/28/15 12:18:48 PM
#1960   Different animal here now IMO Good luck everyone ! Cbdpotential 08/27/15 09:49:02 PM
#1959   DONT forget, FAIL is this companies name. They expediter13 08/27/15 08:48:46 PM
#1958   Potential to see that tall candlestick soon. Bread Man 08/27/15 04:26:36 PM
#1957   Adding Cbdpotential 08/27/15 03:21:09 PM
#1956   Another nice day. 3 in a row. Citrati 08/26/15 11:13:59 PM
#1955   Anyone know the date for this catalyst? Jongkey 08/25/15 02:29:49 PM
#1954   Hard to clear support as of right Black sunshine 08/24/15 10:08:56 PM
#1953   Good close, feeling stronger about this being bottom. Bread Man 08/24/15 04:04:47 PM
#1952   pretty obvious there is some loading going on rivervalley 08/24/15 10:20:50 AM
#1951   IBB getting hammered...down 18.41 to 321.46. Dow Citrati 08/24/15 08:49:49 AM
#1950   This Baker Bros fetish should end in a etradeedge 08/22/15 11:22:37 PM
#1949   I'm not thinking Baker, State Street, Putnam and Citrati 08/22/15 07:58:02 PM
#1948   You have science, big money and progress at Citrati 08/21/15 03:42:36 PM
#1947   Took position today $2.50. Everything looks great. Bread Man 08/21/15 03:40:19 PM
#1946   Finally took a position here today! basssque 08/21/15 03:37:46 PM
#1945   Nice adds everyone. Working on a very nice Citrati 08/21/15 02:09:00 PM
#1944   Added more @ 2.40. Nice average well under Randolph Duke 08/21/15 01:44:59 PM
#1943   Picked up a position here, been adding the Jongkey 08/21/15 12:21:04 PM
#1942   I guess the way I look at this rivervalley 08/21/15 11:59:09 AM
#1941   Hope so. Market is ugly all around. Black sunshine 08/21/15 11:12:15 AM
#1940   who knows how the rest of the day rivervalley 08/21/15 10:00:59 AM
#1939   Jeez guess not. Market selling pressure too Black sunshine 08/20/15 02:19:30 PM
#1938   Back in 2.55 earlier. 2.50 support looking Black sunshine 08/20/15 02:10:33 PM
#1937   Welcome. May the Bakers give us all a Citrati 08/20/15 09:55:36 AM
#1936   Grabbed a starter here $2.53...eom bUrRpPPP! 08/20/15 09:50:49 AM
#1935   Now that is a great chart. Well done. Citrati 08/20/15 09:05:32 AM
#1934   Well said, finding exact bottoms and tops is bUrRpPPP! 08/20/15 05:31:12 AM
#1933   This is a timeframe and type of chart Citrati 08/19/15 11:14:14 PM
#1932   I keep saying I want to start a bUrRpPPP! 08/19/15 06:26:38 PM
#1931   ok croptop 08/18/15 06:59:39 PM
#1930   Yep, today was a tough day on many bio's. Citrati 08/18/15 06:59:07 PM
#1929   Crop you here! don't sell for a loss. stocking4ms 08/18/15 06:03:29 PM
#1928   made my 3rd and last buy on this rivervalley 08/18/15 04:03:50 PM
#1927   I'm not even down 3% from my buy dave86 08/18/15 03:26:56 PM
#1926   will be stopping out here soon...6% drop crazy.. croptop 08/18/15 02:49:29 PM
#1925   The markets are all down today. I didn't dave86 08/18/15 12:21:01 PM
#1924   Come on climb, Idera, climb! Wolf91 08/18/15 10:42:04 AM