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Idera Pharmaceuticals, Inc. (IDRA)

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Last Post: 10/20/2016 10:38:47 AM - Followers: 155 - Board type: Free - Posts Today: 7

The Company has created DNA-based compounds that in preclinical studies act as antagonists of TLR7 and TLR9, such as IMO-3100, or as antagonists of TLRs 7, 8, and 9, such as IMO-8400. The Company is developing IMO-3100, an antagonist of TLR7 and TLR9, for the treatment of psoriasis. It has selected IMO-8400, an antagonist of TLRs 7, 8, and 9, for development in the treatment of autoimmune diseases, with lupus as the initial disease indication. IMO-2055, a TLR9 agonist, is its lead drug candidate for the treatment of cancer. Clinical trials of IMO-2055 completed by the Company or by Merck KGaA include four Phase I clinical trials, of which two were in healthy subjects and two were in refractory cancer patients, and one Phase II clinical trial. The Phase II clinical trial was a monotherapy trial of IMO-2055 in patients with metastatic or recurrent clear cell renal cancer.

In preclinical animal models, the Company TLR7, 8, and 9 agonists have shown adjuvant activity when combined with various types of antigens. It has designed and created a new class of molecules to inhibit gene expression. These gene silencing oligonucleotides, which it refer to as GSOs, are nucleic acid-based and represent a novel approach to selectively, silence gene expression. It is actively engaged in preclinical research with its GSOs that is designed to explore their potential as research reagents and therapeutic agents. In addition to the Company’s clinical programs in autoimmune and inflammatory diseases and in cancer, it has identified TLR drug candidates for applications in the treatment of infectious diseases, respiratory diseases and hematological malignancies, and TLR3 agonists for use as vaccine adjuvants.

IMO-2125, a synthetic DNA-based TLR9 agonist, is its lead candidate for the treatment of chronic hepatitis C virus (HCV), infection. The Company conducted two Phase I clinical trials of IMO-2125 in patients with chronic HCV infection, one in patients with HCV who had not responded to prior treatment and one in combination with ribavirin, an antiviral medication approved for use in combination with interferon-alpha in the treatment of HCV infection, in treatment-naive patients with genotype 1 chronic HCV infection. In addition to the use of TLR9 agonists in oncology applications, it selected IMO-4200 as a lead TLR7 and TLR8 agonist candidate for the treatment of hematological cancers. Its TLR9 agonists are designed to induce immune responses that could be useful in restoring immune system balance. IMO-2134 is its lead TLR9 agonist for asthma and allergies. In addition to use of TLR7, 8, and 9 agonists as vaccine adjuvants, it also has created TLR3 agonists for potential use as vaccine adjuvants.

The Company competes with Dynavax Technologies Corporation, GlaxoSmithKline plc., Pfizer, Inc., VentiRx Pharmaceuticals., Novartis, Dynavax Technologies Corporation, VaxInnate, Inc., Intercell AG, Cytos Biotechnology AG and Celldex Therapeutics, Inc.



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Current Price
Bid Ask Day's Range
IDRA News: Amended Statement of Beneficial Ownership (sc 13d/a) 10/17/2016 06:03:19 AM
IDRA News: Initial Statement of Beneficial Ownership (3) 10/12/2016 06:27:07 PM
IDRA News: Statement of Changes in Beneficial Ownership (4) 10/11/2016 05:47:18 PM
IDRA News: Statement of Beneficial Ownership (sc 13d) 10/11/2016 05:20:29 PM
IDRA News: Current Report Filing (8-k) 10/07/2016 04:56:18 PM
#2667   Shot up to $2 in a blink. I rivervalley 10/20/16 10:38:47 AM
#2666   $1.83 If I still had the means, I'd buy Not Cbdpotential 10/20/16 10:25:39 AM
#2665   Well you folks kicked it pretty good this morning. Citrati 10/20/16 10:22:03 AM
#2664   This is crazy! ... Hey everyone that follows me Fire Cbdpotential 10/20/16 10:09:40 AM
#2663   Keep posting!! It's just been to $1.84. Hopefully chmcnfunds 10/20/16 10:08:30 AM
#2662   Whoa As soon as I posted.. Back over 1.7 Cbdpotential 10/20/16 09:37:37 AM
#2661   Great question I thought my 1.70's were golden :-( Hopefully turns Cbdpotential 10/20/16 09:36:37 AM
#2660   I thought the train was departing shortly after rivervalley 10/19/16 12:01:54 PM
#2659   Can see this clearly on Google finance which chmcnfunds 10/18/16 08:35:06 AM
#2658   Not sure why the links ran together. Here Citrati 10/18/16 12:56:45 AM
#2657   Sometimes timing is rough. Citrati 10/17/16 09:57:43 PM
#2656   As I posted earlier, for better or worse, Cre8tivmynd 10/17/16 05:14:47 PM
#2655   It hasn't even been a full business day nsomniyak 10/17/16 04:20:47 PM
#2654   Wasn't aware of any regulations concerning those or chmcnfunds 10/17/16 04:14:16 PM
#2653   We would not be seeing updated holdings for nsomniyak 10/17/16 03:55:14 PM
#2652   I don't believe it has closed. I'm thinking chmcnfunds 10/17/16 03:17:04 PM
#2651   Thanks. As noted before there is no reason nsomniyak 10/17/16 02:37:30 PM
#2650   Someone emailed Bob Doody on friday. His response Cre8tivmynd 10/17/16 01:56:28 PM
#2649   Not worried. Those things can take a nsomniyak 10/17/16 01:47:27 PM
#2648   Concerning that the offering hasn't closed yet? THEPK5 10/17/16 11:33:43 AM
#2647   Pillar Pharmaceuticals I, LP Maintains 19.9% Stake in chmcnfunds 10/17/16 08:28:54 AM
#2646   I agree Good luck! Cbdpotential 10/15/16 12:54:22 PM
#2645   Let's see how it does over the next rivervalley 10/14/16 04:07:51 PM
#2644   Once it broke $1.80, sell stops were taken Cre8tivmynd 10/14/16 04:04:39 PM
#2643   Back in with some 1.79's. Believe it could rivervalley 10/14/16 03:55:03 PM
#2642   Worth the time to read IMO although from Citrati 10/14/16 02:12:11 PM
#2641   Oversold? Could be... dragon52 10/13/16 02:00:44 AM
#2640   The shorts might try taking out some stops rivervalley 10/12/16 10:18:12 AM
#2639   ;-) Had to be quick on that one! I took Cbdpotential 10/12/16 10:13:45 AM
#2638   lol I wasn't quite quick enough to buy rivervalley 10/12/16 10:08:59 AM
#2637   Great question Would love to buy more cheap That's for sure Cbdpotential 10/12/16 10:03:57 AM
#2636   Good news, they now hold more: chmcnfunds 10/12/16 08:04:13 AM
#2635   Well that was quick profit in ah which rivervalley 10/11/16 07:50:55 PM
#2634   Looking good! $IDRA Thank you Cbdpotential 10/11/16 06:18:37 PM
#2633   Nice to see Baker Bros. Advisors LP hold KarinCA 10/11/16 05:58:39 PM
#2632   BBrothers!? 8-D Cbdpotential 10/11/16 05:27:00 PM
#2631   Hope you make some $ as well if rivervalley 10/11/16 12:24:42 PM
#2630   :-) Hope you nail it. Been a Citrati 10/11/16 12:22:30 PM
#2629   Took a few in the low 1.80's but rivervalley 10/11/16 12:13:20 PM
#2628   I own a big position I m pretty youssef 10/07/16 09:38:05 PM
#2627   * * $IDRA Video Chart 10-07-16 * * ClayTrader 10/07/16 05:22:52 PM
#2626   IDRA in the bounce house on Monday. I JTrader 10/07/16 04:44:15 PM
#2625   Whew!! Incredibly close with 78707 shares traded @ $2.00. chmcnfunds 10/07/16 04:03:35 PM
#2624   Those may have been grants given to directors. Cre8tivmynd 10/07/16 03:28:12 PM
#2623   Surprised down so much because 3 directors should chmcnfunds 10/07/16 03:07:17 PM
#2622   Currently sitting right on support at the 200 rivervalley 10/07/16 01:40:09 PM
#2621   Welcome KarinCA. Look forward to your thoughts Citrati 10/07/16 12:50:53 PM
#2620   I took a small position a few minutes KarinCA 10/07/16 12:38:36 PM
#2619   Yes I would also want to buy below rivervalley 10/07/16 11:27:03 AM
#2618   Nov 11th data as posted by $heff: chmcnfunds 10/07/16 11:05:31 AM