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Idera Pharmaceuticals, Inc. (IDRA)

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Last Post: 7/2/2015 2:11:40 PM - Followers: 125 - Board type: Free - Posts Today: 3



The Company has created DNA-based compounds that in preclinical studies act as antagonists of TLR7 and TLR9, such as IMO-3100, or as antagonists of TLRs 7, 8, and 9, such as IMO-8400. The Company is developing IMO-3100, an antagonist of TLR7 and TLR9, for the treatment of psoriasis. It has selected IMO-8400, an antagonist of TLRs 7, 8, and 9, for development in the treatment of autoimmune diseases, with lupus as the initial disease indication. IMO-2055, a TLR9 agonist, is its lead drug candidate for the treatment of cancer. Clinical trials of IMO-2055 completed by the Company or by Merck KGaA include four Phase I clinical trials, of which two were in healthy subjects and two were in refractory cancer patients, and one Phase II clinical trial. The Phase II clinical trial was a monotherapy trial of IMO-2055 in patients with metastatic or recurrent clear cell renal cancer.


In preclinical animal models, the Company TLR7, 8, and 9 agonists have shown adjuvant activity when combined with various types of antigens. It has designed and created a new class of molecules to inhibit gene expression. These gene silencing oligonucleotides, which it refer to as GSOs, are nucleic acid-based and represent a novel approach to selectively, silence gene expression. It is actively engaged in preclinical research with its GSOs that is designed to explore their potential as research reagents and therapeutic agents. In addition to the Company’s clinical programs in autoimmune and inflammatory diseases and in cancer, it has identified TLR drug candidates for applications in the treatment of infectious diseases, respiratory diseases and hematological malignancies, and TLR3 agonists for use as vaccine adjuvants.


IMO-2125, a synthetic DNA-based TLR9 agonist, is its lead candidate for the treatment of chronic hepatitis C virus (HCV), infection. The Company conducted two Phase I clinical trials of IMO-2125 in patients with chronic HCV infection, one in patients with HCV who had not responded to prior treatment and one in combination with ribavirin, an antiviral medication approved for use in combination with interferon-alpha in the treatment of HCV infection, in treatment-naive patients with genotype 1 chronic HCV infection. In addition to the use of TLR9 agonists in oncology applications, it selected IMO-4200 as a lead TLR7 and TLR8 agonist candidate for the treatment of hematological cancers. Its TLR9 agonists are designed to induce immune responses that could be useful in restoring immune system balance. IMO-2134 is its lead TLR9 agonist for asthma and allergies. In addition to use of TLR7, 8, and 9 agonists as vaccine adjuvants, it also has created TLR3 agonists for potential use as vaccine adjuvants.


The Company competes with Dynavax Technologies Corporation, GlaxoSmithKline plc., Pfizer, Inc., VentiRx Pharmaceuticals., Novartis, Dynavax Technologies Corporation, VaxInnate, Inc., Intercell AG, Cytos Biotechnology AG and Celldex Therapeutics, Inc.

http://www.iderapharma.com/

 


 

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IDRA
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Option Chain for IDRA
IDRA News: Statement of Changes in Beneficial Ownership (4) 07/01/2015 04:36:53 PM
IDRA News: Initial Statement of Beneficial Ownership (3) 07/01/2015 04:35:34 PM
IDRA News: Current Report Filing (8-k) 06/11/2015 04:37:48 PM
IDRA News: Statement of Changes in Beneficial Ownership (4) 06/11/2015 08:11:28 AM
IDRA News: Statement of Changes in Beneficial Ownership (4) 06/10/2015 06:31:41 PM
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#718  Sticky Note Hi Seel. Let me assure you that despite ajsmith 03/09/14 01:35:35 AM
#1835   Without some facts, links, chart interpretation etc that Citrati 07/02/15 02:11:40 PM
#1834   maybe Fibanotch 07/02/15 02:02:25 PM
#1833   Headed lower. MonestHind 07/02/15 09:55:05 AM
#1832   Oh maybe I'm wrong on that.. Either way, Cbdpotential 07/01/15 04:43:12 PM
#1831   Nice insider buys today ;-) Looking good here IMO Cbdpotential 07/01/15 04:39:05 PM
#1830   No kidding. Citrati 06/30/15 05:45:27 PM
#1829   Alerted here too? Seems like when you say Cbdpotential 06/30/15 05:32:33 PM
#1828   LowerMAO Cbdpotential 06/30/15 03:31:09 PM
#1827   A steady close today from here and we Citrati 06/30/15 01:50:29 PM
#1826   Lower. MonestHind 06/29/15 10:31:49 AM
#1825   Pain in the market tomorrow. May see this jembers 06/28/15 09:03:46 PM
#1824   Bring it. I am ready. Citrati 06/28/15 10:38:32 AM
#1823   Nice one day candle, hope it continues. kevindenver 06/27/15 10:57:04 PM
#1822   4$ is coming IMO Glta Cbdpotential 06/27/15 12:19:03 PM
#1821   back in this one today with an initial rivervalley 06/25/15 03:11:29 PM
#1820   3.31 may be tested today, unfortunately. jembers 06/25/15 01:14:48 PM
#1819   I think it's all dependent on Greece and jembers 06/25/15 12:43:49 PM
#1818   I think you are right on both counts Citrati 06/25/15 12:39:55 PM
#1817   Cracked support. Not looking great here, although most jembers 06/25/15 12:28:29 PM
#1816   I've been in this stock for quite a cptjsd 06/25/15 12:43:56 AM
#1815   Exactly. Looking good here IMO Cbdpotential 06/24/15 11:25:15 PM
#1814   Your not going to see green everyday, lol... Citrati 06/24/15 05:36:40 PM
#1813   What the f__k is with this stock? jembers 06/24/15 03:10:23 PM
#1812   What's key support here? THEPK5 06/24/15 09:44:22 AM
#1811   Or not so much..... THEPK5 06/23/15 10:16:53 PM
#1810   Looking good Cbdpotential 06/22/15 09:51:54 AM
#1809   Alright. I'm feeling extra bullish for next week.. Good Cbdpotential 06/17/15 08:51:12 PM
#1808   Damn. Stop losses triggering everywhere. TheHound 06/16/15 03:48:55 PM
#1807   I believe they are calling for $6 Randolph Duke 06/15/15 01:58:37 PM
#1806   WM trial must be going fine, let's remember binchey 06/15/15 08:12:18 AM
#1805   Woohoo! $idra Cbdpotential 06/15/15 07:59:43 AM
#1804   JP Morgan is now covering IDRA, pre-market 3,67 binchey 06/15/15 07:33:08 AM
#1803   4$ will be tough Let's get over than hurdle soon! Cbdpotential 06/15/15 02:29:46 AM
#1802   Down on good news. Not what I Black sunshine 06/09/15 08:24:44 PM
#1801   Collaboration with MD, wow binchey 06/08/15 08:58:08 AM
#1800   would definitely like to keep the 10day upward Citrati 06/05/15 10:48:35 PM
#1799   Will need some power hour or rail will Citrati 06/04/15 01:53:49 PM
#1798   After 10/50 cross looks like it just wants Citrati 06/04/15 10:32:21 AM
#1797   Great post! Go $IDRA Cbdpotential 06/03/15 12:41:08 PM
#1796   Healthy to get back inside the upper bb. Citrati 06/01/15 10:04:04 AM
#1795   Another fantastic post from mgm ----------------------------------------------- binchey 05/30/15 06:44:41 AM
#1794   Your welcome, closure on a day/week high looks binchey 05/29/15 06:20:27 PM
#1793   Great post. Thank you! Seel 05/29/15 06:17:48 PM
#1792   Great Cbdpotential 05/29/15 03:11:17 PM
#1791   awesome week for IDRA. rivervalley 05/29/15 02:25:22 PM
#1790   Above $3.80 now and on what seems to NotRichYet2 05/29/15 01:56:24 PM
#1789   Agreed hogfan2 05/29/15 12:51:08 PM
#1788   Agreed hogfan2 05/29/15 12:51:06 PM
#1787   Back to Baker Bro $20million investment purchase price. Citrati 05/29/15 12:40:53 PM
#1786   email from IDRA to mgm2020 binchey 05/29/15 10:01:19 AM
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