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Idera Pharmaceuticals, Inc. (IDRA)

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Moderator: No Moderator Seel, Black sunshine
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Last Post: 10/6/2015 1:33:54 PM - Followers: 146 - Board type: Free - Posts Today: 0

The Company has created DNA-based compounds that in preclinical studies act as antagonists of TLR7 and TLR9, such as IMO-3100, or as antagonists of TLRs 7, 8, and 9, such as IMO-8400. The Company is developing IMO-3100, an antagonist of TLR7 and TLR9, for the treatment of psoriasis. It has selected IMO-8400, an antagonist of TLRs 7, 8, and 9, for development in the treatment of autoimmune diseases, with lupus as the initial disease indication. IMO-2055, a TLR9 agonist, is its lead drug candidate for the treatment of cancer. Clinical trials of IMO-2055 completed by the Company or by Merck KGaA include four Phase I clinical trials, of which two were in healthy subjects and two were in refractory cancer patients, and one Phase II clinical trial. The Phase II clinical trial was a monotherapy trial of IMO-2055 in patients with metastatic or recurrent clear cell renal cancer.

In preclinical animal models, the Company TLR7, 8, and 9 agonists have shown adjuvant activity when combined with various types of antigens. It has designed and created a new class of molecules to inhibit gene expression. These gene silencing oligonucleotides, which it refer to as GSOs, are nucleic acid-based and represent a novel approach to selectively, silence gene expression. It is actively engaged in preclinical research with its GSOs that is designed to explore their potential as research reagents and therapeutic agents. In addition to the Company’s clinical programs in autoimmune and inflammatory diseases and in cancer, it has identified TLR drug candidates for applications in the treatment of infectious diseases, respiratory diseases and hematological malignancies, and TLR3 agonists for use as vaccine adjuvants.

IMO-2125, a synthetic DNA-based TLR9 agonist, is its lead candidate for the treatment of chronic hepatitis C virus (HCV), infection. The Company conducted two Phase I clinical trials of IMO-2125 in patients with chronic HCV infection, one in patients with HCV who had not responded to prior treatment and one in combination with ribavirin, an antiviral medication approved for use in combination with interferon-alpha in the treatment of HCV infection, in treatment-naive patients with genotype 1 chronic HCV infection. In addition to the use of TLR9 agonists in oncology applications, it selected IMO-4200 as a lead TLR7 and TLR8 agonist candidate for the treatment of hematological cancers. Its TLR9 agonists are designed to induce immune responses that could be useful in restoring immune system balance. IMO-2134 is its lead TLR9 agonist for asthma and allergies. In addition to use of TLR7, 8, and 9 agonists as vaccine adjuvants, it also has created TLR3 agonists for potential use as vaccine adjuvants.

The Company competes with Dynavax Technologies Corporation, GlaxoSmithKline plc., Pfizer, Inc., VentiRx Pharmaceuticals., Novartis, Dynavax Technologies Corporation, VaxInnate, Inc., Intercell AG, Cytos Biotechnology AG and Celldex Therapeutics, Inc.



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Current Price
Bid Ask Day's Range
IDRA News: Statement of Changes in Beneficial Ownership (4) 10/05/2015 07:00:08 PM
IDRA News: Statement of Changes in Beneficial Ownership (4) 10/05/2015 04:36:35 PM
IDRA News: Securities Registration: Employee Benefit Plan (s-8) 08/06/2015 06:52:12 AM
IDRA News: Securities Registration: Employee Benefit Plan (s-8) 08/06/2015 06:51:31 AM
IDRA News: Quarterly Report (10-q) 08/06/2015 06:43:00 AM
#718  Sticky Note Hi Seel. Let me assure you that despite ajsmith 03/09/14 01:35:35 AM
#2054   Yes it will be big someday soon. Black sunshine 10/06/15 01:33:54 PM
#2053   This is a MONSTER stock at the right Sagacious 10/04/15 10:57:53 AM
#2052   but you'll touch AVXL, which has almost exact Seel 10/01/15 11:12:16 PM
#2051   Someone better hope for good news, my bet etradeedge 10/01/15 10:33:40 PM
#2050   Waiting to get back in myself. Biotech Black sunshine 09/29/15 05:53:58 PM
#2049   good move. I did the same- out on Randolph Duke 09/29/15 05:23:54 PM
#2048   I did exit on the bounce at 3.50. Citrati 09/29/15 01:43:22 PM
#2047   IDRA actually not holding up too bad considering Black sunshine 09/28/15 05:51:15 PM
#2046   3-4 Long Cbdpotential 09/28/15 01:48:12 PM
#2045   Nice rebound now. Let's see how rest of Citrati 09/28/15 11:05:46 AM
#2044   You and your peak. I think you THEPK5 09/28/15 10:42:07 AM
#2043   Today it looks like we are again testing Citrati 09/25/15 10:47:36 AM
#2042   Equals the peak?? Popped that this morning. Is THEPK5 09/25/15 09:50:50 AM
#2041   $IDRA a mention in this article! Canoepaddler 09/23/15 07:41:24 PM
#2040   $3.86 = Mt Everest Black sunshine 09/23/15 04:49:30 PM
#2039   Thanks. Let me digest and see what THEPK5 09/23/15 01:36:27 PM
#2038   Shake out before the BREAKOUT! Let's roll IDRA! I'M NOT THEPK5 09/23/15 01:34:26 PM
#2037   I will be gone today, but work on Citrati 09/23/15 10:09:21 AM
#2036   Care to give some insight on charting? What's the THEPK5 09/23/15 09:40:16 AM
#2035   Some institutional buying and short covering going on Canoepaddler 09/22/15 10:43:46 PM
#2034   Truth Cbdpotential 09/22/15 07:22:00 PM
#2033   Probably hit $5 as soon as it gains kevindenver 09/22/15 06:09:15 PM
#2032   I have also SYN, CPRX and IPCI. IDRA stocking4ms 09/22/15 03:17:14 PM
#2031   Guess no one else but us here to Citrati 09/22/15 02:55:01 PM
#2030   This has got to be the most bass THEPK5 09/22/15 11:11:13 AM
#2029   Look at that last 5 minute volume bar Citrati 09/22/15 10:31:53 AM
#2028   Ouch. whatever the reason, working on a large Citrati 09/21/15 12:20:13 PM
#2027   A good question. What remains to be seen Citrati 09/21/15 10:05:36 AM
#2026   Devils advocate here.....and non-expert to boot.... Doesn't that mean THEPK5 09/21/15 09:42:42 AM
#2025   A good chance we are just getting started. Citrati 09/19/15 12:45:44 PM
#2024   I cannot remember the #'s, but I do Citrati 09/19/15 11:39:33 AM
#2023   5$ Cbdpotential 09/19/15 07:10:21 AM
#2022   Taking profits was a bad idea yesterday .... :-( But Cbdpotential 09/19/15 07:09:31 AM
#2021   Was the very high volume due to Triple Black sunshine 09/18/15 06:48:13 PM
#2020   That makes you either Julien or Felix unless Citrati 09/18/15 05:45:02 PM
#2019   It was me. I finally decided to THEPK5 09/18/15 05:35:30 PM
#2018   You too C! Seel 09/18/15 05:03:59 PM
#2017   No idea. If it's not you it must Citrati 09/18/15 05:01:26 PM
#2016   Wow! That happened? That is great! Seel 09/18/15 04:56:15 PM
#2015   Just curious which one of you whales bought Citrati 09/18/15 04:36:21 PM
#2014   LOL, you can't hide, I see your smiles. Citrati 09/18/15 04:03:34 PM
#2013   Which one of you started this rebound off? Citrati 09/17/15 02:54:43 PM
#2012   There will be ups and downs, but IDRA Citrati 09/16/15 10:39:53 PM
#2011   Fed will be a non event IMO. Canoepaddler 09/16/15 09:41:44 PM
#2010   Yea, pretty nasty today but it will recover ryansk23 09/16/15 03:59:17 PM
#2009   Sold the news and then some. Ugly Black sunshine 09/16/15 02:49:10 PM
#2008   Simple. People sold the news. ryansk23 09/16/15 02:21:28 PM
#2007   Then why down 6% today. Something not THEPK5 09/16/15 02:04:06 PM
#2006   "Additionally, Idera announced that pre-clinical data relating to Canoepaddler 09/16/15 01:43:00 PM
#2005   Thanks for that CHM....great dd. Citrati 09/16/15 10:03:21 AM