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Idera Pharmaceuticals, Inc. (IDRA)

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Last Post: 7/30/2015 1:07:24 PM - Followers: 128 - Board type: Free - Posts Today: 0



The Company has created DNA-based compounds that in preclinical studies act as antagonists of TLR7 and TLR9, such as IMO-3100, or as antagonists of TLRs 7, 8, and 9, such as IMO-8400. The Company is developing IMO-3100, an antagonist of TLR7 and TLR9, for the treatment of psoriasis. It has selected IMO-8400, an antagonist of TLRs 7, 8, and 9, for development in the treatment of autoimmune diseases, with lupus as the initial disease indication. IMO-2055, a TLR9 agonist, is its lead drug candidate for the treatment of cancer. Clinical trials of IMO-2055 completed by the Company or by Merck KGaA include four Phase I clinical trials, of which two were in healthy subjects and two were in refractory cancer patients, and one Phase II clinical trial. The Phase II clinical trial was a monotherapy trial of IMO-2055 in patients with metastatic or recurrent clear cell renal cancer.


In preclinical animal models, the Company TLR7, 8, and 9 agonists have shown adjuvant activity when combined with various types of antigens. It has designed and created a new class of molecules to inhibit gene expression. These gene silencing oligonucleotides, which it refer to as GSOs, are nucleic acid-based and represent a novel approach to selectively, silence gene expression. It is actively engaged in preclinical research with its GSOs that is designed to explore their potential as research reagents and therapeutic agents. In addition to the Company’s clinical programs in autoimmune and inflammatory diseases and in cancer, it has identified TLR drug candidates for applications in the treatment of infectious diseases, respiratory diseases and hematological malignancies, and TLR3 agonists for use as vaccine adjuvants.


IMO-2125, a synthetic DNA-based TLR9 agonist, is its lead candidate for the treatment of chronic hepatitis C virus (HCV), infection. The Company conducted two Phase I clinical trials of IMO-2125 in patients with chronic HCV infection, one in patients with HCV who had not responded to prior treatment and one in combination with ribavirin, an antiviral medication approved for use in combination with interferon-alpha in the treatment of HCV infection, in treatment-naive patients with genotype 1 chronic HCV infection. In addition to the use of TLR9 agonists in oncology applications, it selected IMO-4200 as a lead TLR7 and TLR8 agonist candidate for the treatment of hematological cancers. Its TLR9 agonists are designed to induce immune responses that could be useful in restoring immune system balance. IMO-2134 is its lead TLR9 agonist for asthma and allergies. In addition to use of TLR7, 8, and 9 agonists as vaccine adjuvants, it also has created TLR3 agonists for potential use as vaccine adjuvants.


The Company competes with Dynavax Technologies Corporation, GlaxoSmithKline plc., Pfizer, Inc., VentiRx Pharmaceuticals., Novartis, Dynavax Technologies Corporation, VaxInnate, Inc., Intercell AG, Cytos Biotechnology AG and Celldex Therapeutics, Inc.

http://www.iderapharma.com/

 


 

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IDRA News: Statement of Changes in Beneficial Ownership (4) 07/06/2015 06:46:41 PM
IDRA News: Statement of Changes in Beneficial Ownership (4) 07/06/2015 06:26:55 PM
IDRA News: Statement of Changes in Beneficial Ownership (4) 07/01/2015 04:36:53 PM
IDRA News: Initial Statement of Beneficial Ownership (3) 07/01/2015 04:35:34 PM
IDRA News: Current Report Filing (8-k) 06/11/2015 04:37:48 PM
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#718  Sticky Note Hi Seel. Let me assure you that despite ajsmith 03/09/14 01:35:35 AM
#1888   ST weakness did take over. Testing the bottom Citrati 07/30/15 01:07:24 PM
#1887   While I understand the "weak" comment, I do Citrati 07/28/15 03:34:09 PM
#1886   Weak, even on a big IBB green day binks 07/28/15 02:48:28 PM
#1885   Looks like we are in the process of Citrati 07/26/15 10:02:00 PM
#1884   Getting a nice recovery EOD here binks 07/24/15 03:23:39 PM
#1883   Good consolidation today imo... Should bounce next week quicktrader 07/24/15 03:21:52 PM
#1882   biogen effect, heavy sell off binchey 07/24/15 03:06:54 PM
#1881   Huge tankage on the IBB today binks 07/24/15 02:16:19 PM
#1880   Well....didn't have to be too patient! THEPK5 07/24/15 01:59:36 PM
#1879   Just have to guess or be patient until Citrati 07/24/15 11:11:51 AM
#1878   Shoot....almost added this morning @ $3.78. THEPK5 07/24/15 11:06:19 AM
#1877   Looking good $idra Cbdpotential 07/24/15 09:45:21 AM
#1876   I hear ya.. I sold too low and Cbdpotential 07/23/15 09:05:32 PM
#1875   Yeah thinking of getting back in depending on Black sunshine 07/23/15 09:04:09 PM
#1874   If this can stay above 4$ next week.. Cbdpotential 07/23/15 03:41:23 PM
#1873   Thanks C Well said Stay green ! Cbdpotential 07/23/15 03:40:47 PM
#1872   Aloha: Lovely trading day here! The little company Denise Chanterelle 07/23/15 02:41:51 PM
#1871   Just to add to Cbd comments. Citrati 07/23/15 01:59:35 PM
#1870   That's ok. Don't ever kick yourself for protecting Cbdpotential 07/23/15 11:10:09 AM
#1869   Arghh...Sold at 3.94 today :( Black sunshine 07/23/15 10:58:54 AM
#1868   4$ now... Time for a rainbow magic trade yes? Cbdpotential 07/23/15 10:48:27 AM
#1867   4$ is here! Next stop.. 5$ ;-) Cbdpotential 07/23/15 10:45:42 AM
#1866   Congrats. I can see clearly now. Citrati 07/23/15 12:35:40 AM
#1865   Added some more about 1k shares Easy breakout to Cbdpotential 07/22/15 11:51:28 AM
#1864   Lovin it Cbdpotential 07/22/15 11:02:01 AM
#1863   here we roll !!! breakout time StOckTool 07/21/15 02:48:13 PM
#1862   I still scoop it up on dips C. Seel 07/20/15 06:51:48 PM
#1861   FWIW as they were an underwriter. Piper Jaffrey Citrati 07/19/15 07:42:46 PM
#1860   Still trading in its channel with a slightly Citrati 07/19/15 07:10:16 PM
#1859   Looks like price suppression to me. Institutions Black sunshine 07/15/15 07:21:40 PM
#1858   Short interest. noviceinvestor08 07/13/15 07:28:50 AM
#1857   Frankly C, I have nothing against traders. If Seel 07/10/15 08:52:47 PM
#1856   Thanks for the gracious supporting words Seel. Citrati 07/10/15 03:22:54 PM
#1855   Ditto!!! hogfan2 07/09/15 07:04:09 PM
#1854   Definitely! Citrati backs up every statement with an Seel 07/09/15 06:02:06 PM
#1853   Trades done. We'll keep it on watch but MonestHind 07/09/15 02:53:37 PM
#1852   Amazing hogfan2 07/09/15 01:45:17 PM
#1851   LOL, can't answer a direct question, huh! Citrati 07/09/15 11:20:02 AM
#1850   No that's not at all what I'm saying. MonestHind 07/09/15 11:02:27 AM
#1849   Ok, so are you saying 3.34 was the Citrati 07/09/15 11:00:47 AM
#1848   Already hit it. MonestHind 07/09/15 10:57:22 AM
#1843   LOL, useless IDRA post IMO. Never called a Citrati 07/08/15 05:10:10 PM
#1842   We were SPOT ON with our recent IDRA MonestHind 07/08/15 03:57:13 PM
#1841   NEWS PLEASE !!! ;-) Cbdpotential 07/08/15 10:42:54 AM
#1840   The ocean is rough lately and it is Citrati 07/08/15 10:41:51 AM
#1839   Higher Cbdpotential 07/08/15 08:35:21 AM
#1838   Interesting article: stocking4ms 07/08/15 04:18:49 AM
#1837   Awesome! Thanks! MrW 07/03/15 09:17:33 PM
#1836   For the last 5 weeks IDRA has been Citrati 07/03/15 02:27:47 PM
#1835   Without some facts, links, chart interpretation etc that Citrati 07/02/15 02:11:40 PM
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