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Idera Pharmaceuticals, Inc. (IDRA)

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Last Post: 2/4/2016 5:26:41 PM - Followers: 155 - Board type: Free - Posts Today: 0

The Company has created DNA-based compounds that in preclinical studies act as antagonists of TLR7 and TLR9, such as IMO-3100, or as antagonists of TLRs 7, 8, and 9, such as IMO-8400. The Company is developing IMO-3100, an antagonist of TLR7 and TLR9, for the treatment of psoriasis. It has selected IMO-8400, an antagonist of TLRs 7, 8, and 9, for development in the treatment of autoimmune diseases, with lupus as the initial disease indication. IMO-2055, a TLR9 agonist, is its lead drug candidate for the treatment of cancer. Clinical trials of IMO-2055 completed by the Company or by Merck KGaA include four Phase I clinical trials, of which two were in healthy subjects and two were in refractory cancer patients, and one Phase II clinical trial. The Phase II clinical trial was a monotherapy trial of IMO-2055 in patients with metastatic or recurrent clear cell renal cancer.

In preclinical animal models, the Company TLR7, 8, and 9 agonists have shown adjuvant activity when combined with various types of antigens. It has designed and created a new class of molecules to inhibit gene expression. These gene silencing oligonucleotides, which it refer to as GSOs, are nucleic acid-based and represent a novel approach to selectively, silence gene expression. It is actively engaged in preclinical research with its GSOs that is designed to explore their potential as research reagents and therapeutic agents. In addition to the Company’s clinical programs in autoimmune and inflammatory diseases and in cancer, it has identified TLR drug candidates for applications in the treatment of infectious diseases, respiratory diseases and hematological malignancies, and TLR3 agonists for use as vaccine adjuvants.

IMO-2125, a synthetic DNA-based TLR9 agonist, is its lead candidate for the treatment of chronic hepatitis C virus (HCV), infection. The Company conducted two Phase I clinical trials of IMO-2125 in patients with chronic HCV infection, one in patients with HCV who had not responded to prior treatment and one in combination with ribavirin, an antiviral medication approved for use in combination with interferon-alpha in the treatment of HCV infection, in treatment-naive patients with genotype 1 chronic HCV infection. In addition to the use of TLR9 agonists in oncology applications, it selected IMO-4200 as a lead TLR7 and TLR8 agonist candidate for the treatment of hematological cancers. Its TLR9 agonists are designed to induce immune responses that could be useful in restoring immune system balance. IMO-2134 is its lead TLR9 agonist for asthma and allergies. In addition to use of TLR7, 8, and 9 agonists as vaccine adjuvants, it also has created TLR3 agonists for potential use as vaccine adjuvants.

The Company competes with Dynavax Technologies Corporation, GlaxoSmithKline plc., Pfizer, Inc., VentiRx Pharmaceuticals., Novartis, Dynavax Technologies Corporation, VaxInnate, Inc., Intercell AG, Cytos Biotechnology AG and Celldex Therapeutics, Inc.



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Current Price
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IDRA News: Current Report Filing (8-k) 01/11/2016 08:49:27 AM
IDRA News: Statement of Changes in Beneficial Ownership (4) 01/08/2016 04:48:50 PM
IDRA News: Statement of Changes in Beneficial Ownership (4) 01/08/2016 04:48:24 PM
IDRA News: Statement of Changes in Beneficial Ownership (4) 01/08/2016 04:48:02 PM
IDRA News: Statement of Changes in Beneficial Ownership (4) 01/08/2016 04:47:34 PM
#718  Sticky Note Hi Seel. Let me assure you that despite ajsmith 03/09/14 01:35:35 AM
#2326   Wish you the best as well. Citrati 02/04/16 05:26:41 PM
#2325   How's the 1.90 looking? Sat there today for Youlie 02/04/16 05:11:20 PM
#2324   nice, let's hope next week is a good rivervalley 01/30/16 09:51:43 AM
#2323   Great opportunity here IMO ;-) Cbdpotential 01/30/16 12:12:05 AM
#2322   I bought some over the last two days here. Canoepaddler 01/29/16 09:42:32 PM
#2321   Nice close above the 10 MA. Chart is rivervalley 01/29/16 04:33:22 PM
#2320   Now in the larger wedge, triangle, while still Citrati 01/29/16 12:24:37 PM
#2319   Hi the hound I m investing heavy on youssef 01/28/16 08:11:14 PM
#2318   Two very interesting triangles IMO. Citrati 01/28/16 12:10:57 PM
#2317   IBB new 52 week low. Bios still Citrati 01/28/16 10:02:34 AM
#2316   Settlement Date Short Interest Avg Daily Share Volume rivervalley 01/28/16 06:39:42 AM
#2315   Let's see if we get a bullish cross rivervalley 01/27/16 09:46:40 AM
#2314   I'll be honest, I haven't made a dime TheHound 01/26/16 11:36:03 PM
#2313   Ya know. They just won't make it easy. Citrati 01/26/16 11:33:03 PM
#2312   Not sure C. I've backed off just a bit. TheHound 01/26/16 11:28:38 PM
#2311   Dow up 200 plus and IDRA down. Surprised Citrati 01/26/16 10:42:04 AM
#2310   Held up nicely for a 200 point down Citrati 01/25/16 04:00:56 PM
#2309   Curious to see the short interest on the rivervalley 01/24/16 04:55:23 PM
#2308   Can't confirm anything for 4Q yet. Might have Citrati 01/24/16 04:37:47 PM
#2307   Interested to know if you find anything C. TheHound 01/23/16 12:36:48 PM
#2306   :-) Have a great weekend C. TheHound 01/23/16 12:30:11 PM
#2305   "So it is written so shall it be done" Citrati 01/23/16 12:22:08 PM
#2304   This one is going up. Hang tight. TheHound 01/22/16 07:41:59 PM
#2303   You have a good one too Citrati, as rivervalley 01/22/16 03:52:03 PM
#2302   I haven't had time, but I want to Citrati 01/22/16 03:49:43 PM
#2301   Does this seem like a bit too much rivervalley 01/22/16 03:44:26 PM
#2300   LOL, it's like winning the lottery. Catching bottoms Citrati 01/22/16 03:40:02 PM
#2299   Good to see some interest at this level. rivervalley 01/22/16 01:56:19 PM
#2298   I just picked up a few k on TheHound 01/22/16 01:47:19 PM
#2297   I think this is where this one is rivervalley 01/22/16 01:34:17 PM
#2296   Pinch setting up after the DCB looks like BooDog 01/22/16 05:32:04 AM
#2295   Yes an excellent pps,congrats. I had added some rivervalley 01/21/16 10:31:47 AM
#2294   I was able to add some IDRA at nsomniyak 01/21/16 09:05:18 AM
#2292   hopefully we get a continuation in the coming rivervalley 01/20/16 03:41:12 PM
#2290   What a ride. Go IDRA! TheHound 01/20/16 01:27:40 PM
#2289   Brutal. Even my gold mining stock down Black sunshine 01/20/16 10:32:44 AM
#2288   The market overreaction across this sector amazes me. TheHound 01/20/16 10:05:21 AM
#2287   Your not alone buddy. No one is doing W&T Capital LLC 01/20/16 08:08:43 AM
#2286   Was probably just a rebalancing from normal trading Black sunshine 01/19/16 10:51:07 PM
#2285   Been here before and bounced. Obvious sellers market Randolph Duke 01/19/16 07:14:51 PM
#2284   Interesting 25k after hours trade at $1.94. TheHound 01/19/16 05:46:29 PM
#2283   Another $1500 down on this thing today. Black sunshine 01/19/16 04:39:28 PM
#2282   yeah me too, and it isn't the first rivervalley 01/19/16 04:12:26 PM
#2281   I got my ass kicked today. FFS. TheHound 01/19/16 03:55:35 PM
#2280   seems there would be enough buying down at rivervalley 01/19/16 03:50:31 PM
#2279   Wow. Just wow. TheHound 01/19/16 02:13:20 PM
#2278   Green it shall be ! :-D Cbdpotential 01/18/16 06:14:27 AM
#2277   Haha. Thanks. Citrati 01/15/16 10:55:02 PM
#2276   ;-) haven't checked my email yet but look TheHound 01/15/16 10:37:43 PM
#2275   LOL, Hound. It looks like you are reading Citrati 01/15/16 10:35:32 PM