Cyclacel Pharmaceuticals, Inc., a development-stage biopharmaceutical company, engages in the discovery, development, and commercialization of novel, mechanism-targeted drugs to treat human cancers and other serious disorders. Its orally-available drugs in clinical development include Sapacitabine (CYC682), an oral nucleoside analogue, which is in phase II studies for the treatment of hematological malignancies, such as acute myeloid leukemia in the elderly, myelodysplastic syndromes, cutaneous T-cell lymphoma, and lung cancer; Seliciclib (CYC202), a CDK (cyclin dependent kinase) inhibitor, which is in phase II studies for the treatment of lung cancer and nasopharyngeal cancer; and CYC116, an Aurora kinase and VEGFR2 inhibitor that is in phase I studies for patients with solid tumors. The company, through its subsidiary, ALIGN Pharmaceuticals, LLC, markets directly Xclair Cream for radiation dermatitis, as well as Numoisyn Liquid and Numoisyn Lozenges for xerostomia in the United States. It focuses on building a diversified biopharmaceutical business focused in hematology, oncology, and other therapeutic areas based on a portfolio of commercial products and a development pipeline of novel drug candidates. The company was founded in 1992 and is headquartered in Berkeley Heights, New Jersey.
Applying its core strength in cell cycle biology, Cyclacel is advancing a pipeline of orally available, small molecule, investigational drugs designed to stop uncontrolled cell division. Sapacitabine, our lead drug candidate, is being evaluated in the SEAMLESS pivotal Phase 3 trial in elderly patients with acute myeloid leukemia under a Special Protocol Assessment agreement with the US Food and Drug Administration. For more information on our investigational drug programs and clinical trials, please go to the Research & Development tab above.
Learn more about our clinical trials:
An oral nucleoside analogue prodrug that acts through a novel mechanism.
A novel, first-in-class, orally available, cyclin dependent kinase (CDK) inhibitor.
An orally-active inhibitor of Aurora kinases A & B and VEGFR2.