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Carbylan Therapeutics, Inc. (CBYL)

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Last Post: 10/20/2016 9:41:32 PM - Followers: 19 - Board type: Free - Posts Today: 0
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Our research and development efforts have focused on developing a proprietary versatile methodology to cross-link hyaluronic acid to form hydrogels. This methodology is versatile because slight alterations in the formula allow us to prepare hydrogels that can be pre-formed or prepared on site and can range in texture from soft to hard gels. The chemistry used to cross-link the hyaluronic acid does not produce harmful reaction by-products that must be removed from the hydrogel during the manufacturing process. This enables the direct incorporation of biologically-active agents into the hydrogel without the need for further purification. Thus, these prepared hydrogels can be used directly without further processing. Additionally, biologically-active agents such as small molecule drugs, certain proteins and cells can be incorporated into the hydrogel. Such hydrogel formulations can be applied topically or parenterally.

Carbylan Therapeutics, Inc., a specialty pharmaceutical company, focuses on the development and commercialization of novel and proprietary combination therapies. Its product candidate is Hydros-TA, which has completed Phase IIb clinical trial designed to provide rapid and sustained relief from pain associated with osteoarthritis. The company was formerly known as Carbylan Biosurgery, Inc. and changed its name to Carbylan Therapeutics, Inc. in March 2014. Carbylan BioSurgery, Inc. was founded in 2004 and is headquartered in Palo Alto, California.

Clinical Studies

Clinical Studies

Our Phase 2b clinical trial of Hydros-TA, known as COR1.0, was a prospective, multicenter, randomized, double-blind feasibility study to evaluate the safety and performance of Hydros-TA in subjects with OA of the knee. Eight clinical centers in Canada, Europe and the Caribbean participated in the COR1.0 trial. A total of 98 subjects were enrolled, treated and followed for six months post-treatment. Subjects were randomized 1:1:1 to receive a single 6mL intra-articular injection of one of three study treatments: Hydros- TA, Hydros (the viscosupplement without steroid) and Synvisc-One (the U.S. market leading HA viscosupplement).
Key Observations from COR1.0: The results from COR1.0 suggest that a single injection of Hydros-TA was well-tolerated and could relieve pain associated with symptomatic OA of the knee over 26 weeks. Although not statistically significant, Hydros-TA demonstrated a numerically higher pain relief at all time points after injection when compared with Synvisc-One and the percentage of subjects who responded favorably to the product as measured by the OMERACT-OARSI responder rate was higher in the Hydros and Hydros-TA groups when compared to Synvisc-One.
To our knowledge, this is the first clinical study to report on the safety and effectiveness of a single-injection viscosupplement that combines HA and corticosteroid for the treatment of knee OA. Reductions in WOMAC pain scores observed in this study suggest that this combination may have a faster onset of pain relief compared to non-steroid containing products and may provide improved pain relief over the full 26 weeks post injection. These results reflect a synergistic effect of combining HA with a corticosteroid.
Phase 3 Clinical Trial Program
The first of our two pivotal Phase 3 trials began enrollment in mid-January 2014. We are actively enrolling up to 510 subjects at 30 to 40 sites in Australia, Canada, New Zealand, Europe and the Caribbean.

2015 News Releases

Date Title  
04/14/15 Carbylan Therapeutics, Inc. Announces Closing of Initial Public Offering and Full Exercise of Underwriters' Option to Purchase Additional Shares Printer Friendly Version
04/08/15 Carbylan Therapeutics, Inc. Announces Pricing of Initial Public Offering Printer Friendly Version

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Current Price
Bid Ask Day's Range
CBYL News: Proxy Soliciting Materials (revised) (prer14a) 09/30/2016 04:59:47 PM
CBYL News: Current Report Filing (8-k) 09/30/2016 04:10:22 PM
CBYL News: Carbylan Shareholder (CBYL) Alert: Shareholder Rights Law Firm Johnson & Weaver, LLP Continues its Investigation of Carbylan... 09/23/2016 07:53:00 AM
CBYL News: Amended Statement of Ownership (sc 13g/a) 09/12/2016 01:38:46 PM
CBYL News: Proxy Statement - Merger or Acquistion (preliminary) (prem14a) 08/24/2016 06:02:54 AM
#357  Sticky Note Why the merger of CBYL with a private Value_Investor 10/08/16 08:45:56 PM
#336  Sticky Note Problem is, they've giving that cash away for Toxic Avenger 10/01/16 05:06:09 AM
#374   Another Green day! CBYL hit a new high Value_Investor 10/20/16 09:41:32 PM
#373   We closed green yesterday. Hopefully today will be thedetailguyz 10/20/16 08:01:04 AM
#372   CBYL hit the higher high $0.506 today after Value_Investor 10/19/16 11:19:32 PM
#371   I hope so, but I'd really like to Toxic Avenger 10/18/16 07:54:19 PM
#370   Finally CBYL broke up yesterday's high 0.4999 today Value_Investor 10/18/16 07:02:17 PM
#369   Nice to see the higher high $0.4999 today Value_Investor 10/17/16 10:57:29 PM
#368   Obviously the majority of CBYL shareholders don't like Value_Investor 10/17/16 10:20:08 AM
#367   I suspect as it looks more and more Toxic Avenger 10/17/16 08:58:56 AM
#366   This thing is tanking and nobody knows why. thedetailguyz 10/17/16 08:49:10 AM
#365   The current Cash Liquidation Value of CBYL is Value_Investor 10/16/16 11:55:08 PM
#364   If all the individual shareholders plus a couple Value_Investor 10/15/16 07:40:17 PM
#363   LOL, yesterday the high was $0.5031 with Tens Value_Investor 10/14/16 01:18:32 PM
#362   No, I don't think so. I'll vote all Value_Investor 10/13/16 09:08:21 AM
#361   Because the horrible merger is likely to go through. Toxic Avenger 10/12/16 03:10:37 PM
#360   LOL, CBYL just rose to $0.57 a couple Value_Investor 10/12/16 01:23:41 PM
#359   CBYL is up 8.7% in the After-Hour session Value_Investor 10/10/16 08:09:04 PM
#358   Who are asking total 102K shares at 0.55 Value_Investor 10/10/16 03:33:06 PM
#357   Why the merger of CBYL with a private Value_Investor 10/08/16 08:45:56 PM
#356   The biggest Nasdaq pos scam just hit $0.4803! Value_Investor 10/07/16 01:43:40 PM
#355   CBYL is acting like a pos scam today! Value_Investor 10/07/16 11:31:49 AM
#354   Welcome to the CBYL board! CBYL is on Value_Investor 10/06/16 06:18:07 PM
#353   CBYL looking good during power hour. I'm keeping JGold5 10/06/16 03:14:18 PM
#352   Who is that very stupid seller which put Value_Investor 10/06/16 01:39:39 PM
#351   I like the way you think, but I Toxic Avenger 10/05/16 01:45:25 PM
#350   I've already bought over 1% of CBYL shares Value_Investor 10/05/16 12:49:11 PM
#349   Good luck. I don't think retail will beat Toxic Avenger 10/04/16 05:20:12 PM
#348   In order to break that deal we all Value_Investor 10/04/16 04:26:31 PM
#347   This is going to be every securities lawyer's Toxic Avenger 10/04/16 09:35:05 AM
#346   Let's hope the deal gets rejected so we Toxic Avenger 10/03/16 10:40:53 AM
#345   Not at all! The "market" knows nothing about Value_Investor 10/03/16 10:31:41 AM
#344   The market has already spoken in devaluing CBYL's Toxic Avenger 10/03/16 05:15:36 AM
#343   Liquidation for all the CBYL shareholders is the Value_Investor 10/02/16 11:02:45 PM
#342   Are you sure? I believe the split was Toxic Avenger 10/02/16 11:56:43 AM
#341   Split 1-14 monday harmsen 10/02/16 10:09:34 AM
#340   Yeah, and CBYL's drugs "could have" been worth billions. Toxic Avenger 10/02/16 05:49:07 AM
#339   That has nothing to do with my calculation, Toxic Avenger 10/02/16 05:47:46 AM
#338   The combined company will have total $48.011M Net Value_Investor 10/01/16 11:36:02 PM
#337   Wrong! The mew company contributes $17.832M cash while Value_Investor 10/01/16 11:31:57 PM
#336   Problem is, they've giving that cash away for Toxic Avenger 10/01/16 05:06:09 AM
#335   CBYL is the only Nasdaq Bio-Tech stock whose Value_Investor 09/28/16 10:28:32 AM
#334   CBYL was Up 1.83% in AH session of Value_Investor 09/24/16 05:31:00 PM
#333   Yes, CBYL is on fire today! It just Value_Investor 09/23/16 02:32:02 PM
#332   Here we go!!!!! harmsen 09/23/16 01:27:57 PM
#331   Nice! CBYL is the Unique Cheapest Bio-Tech Nasdaq Value_Investor 09/16/16 03:24:26 PM
#330   In with 10000 shares 0,48 harmsen 09/16/16 03:00:09 PM
#329   Good news today! One Big Institution just filed Value_Investor 09/12/16 03:30:57 PM
#328   Insiders buying and not reporting is illegal. You Toxic Avenger 09/12/16 08:47:28 AM
#327   I'm not sure but I think this is MrSparex 09/12/16 07:36:18 AM
#326   CBYL has Zero-Debt now which is a Sought-After Value_Investor 09/11/16 06:42:47 PM
#325   That was about as vague and worthless a Toxic Avenger 09/11/16 12:27:04 AM